No abstract

The cage-type MIL-100(Fe) metal-organic frameworks (MOFs) were used as matrices for surface assisted laser desorption-ionization mass spectrometry. The unique 3D cage frameworks and the iron-center feature good reproducibility of MS intensity and a high signal-to-noise ratio compared to organic or other nanoparticle matrices.

Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) represents a powerful tool for the analysis of biomolecules, synthetic polymers, and even small organic compounds; its performances largely depend on the type of matrix materials utilized. Here, for the first time the employment of nanoporous carbons derived from metal-organic frameworks (MOFs) as novel matrices for SALDI-MS is demonstrated. The nanoporous carbons derived from MOFs not only circumvent the shortcomings of existing matrix materials but also demonstrate much higher efficiency of laser desorption/ionization for various compounds than any other nanoporous carbons reported so far. A new perspective for the development of matrix materials for SALDI-MS application is therefore provided.

A simple preparation method of N-doped PCM via direct carbonization of nitrogen containing metal-organic gel was demonstrated. The resultant N-PCM, with high surface area, mesoporosity, and high UV absorption ability, was used as a matrix to assist small-biomolecule sensing in laser desorption/ionization mass spectrometry.