Metal–organic frameworks: new matrices for surface-assisted laser desorption–ionization mass spectrometry

Shih, Yung Han; Chien, Ching Hsuan; Singco, Brenda; Hsu, Chang Lin; Lin, Chia Her; Huang, Hsi Ya

doi:10.1039/c3cc40934a

Cited by 75 publications

(39 citation statements)

References 21 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, MOFs could provide high absorption efficiency in the UV-visible range, which meets the requirement of matrix for LDI. As a result, MOFs as a matrix for LDI-TOF MS for the analysis of small molecules was first introduced by Huang’s group in 2013 [75]. In this work, several porous MOFs (MIL-100 (Fe), MIL-100 (Cr), MIL-100 (Al), MIL-101 (Cr), DUT-4 (Al), DUT-5 (Al) and CYCU-3 (Al)) were synthesized and used as matrices for LDI-MS (Figure 2).…”

Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

View full text Add to dashboard Cite

Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.

show abstract

Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Hence, vortex was employed to enhance the extraction efficiency by 13 vigorously mixing the sample solution with the sorbent. The intensities of the chromatographic signals as the vortex time increased from 0 to 4 min are shown in Fig.…”

Section: Influence Of Vortex Time For Dispersive Spe Proceduresmentioning

confidence: 99%

“…Explorations of MOFs in the analytical chemistry field show interesting potential applications as solid-phase extraction (SPE) [5][6][7], and solid-phase microextraction (SPME) [8,9] sorbents, capillary gas chromatographic (GC) coating phases [10][11][12], matrix-assisted laser 3 desorption/ionization-mass spectrometry matrix [13], , and as biosensors [14]. Certain types of MOFs have properties which endow them with humidity or chemical stability, so that they can be easily utilized in practice.…”

Section: Introductionmentioning

confidence: 99%

Performance of metal-organic framework MIL-101 after surfactant modification in the extraction of endocrine disrupting chemicals from environmental water samples

Huang

Lee

2015

Talanta

View full text Add to dashboard Cite

“…In particular, MOFs can provide high adsorption capability in the UV‐visible range, which meet the requirements to serve as LDI matrices. Since the first report on MOFs as matrices for LDI‐TOF MS, several encouraging works on MOFs‐based negative ion LDI‐TOF MS for small molecules have been reported . For instance, our group developed a facile and efficient strategy to fabricate well‐defined core‐shell Fe 3 O 4 @zeolitic imidazolate frameworks (ZIF‐8) by using Fe 3 O 4 as magnetic core, Zn 2+ ion as connector and 2‐methylimidazole (HMeIM) as linker, respectively.…”

Section: Nanostructured Substrates For Negative Ion Ldi‐tof Msmentioning

confidence: 99%

“…83,84 In particular, MOFs can provide high adsorption capability in the UV-visible range, which meet the requirements to serve as LDI matrices. Since the first report on MOFs as matrices for LDI-TOF MS, 36 several encouraging works on MOFs-based negative ion LDI-TOF MS for small molecules have been reported. 37,85,86 For instance, our group 37 developed a facile and efficient strategy to In addition to the Au NPs, other metal nanoparticles were also used as a matrix in LDI-TOF MS. For example, Pt nanoflowers coated with a fluorocarbon chain (FDTS-Pt Nfs) chip was served as matrix for negative ionization of amino acids.…”

Section: Metal-organic Framework-based Substratesmentioning

confidence: 99%

Negative ion laser desorption/ionization time‐of‐flight mass spectrometric analysis of small molecules by using nanostructured substrate as matrices

Lin

Cai

2018

Mass Spectrometry Reviews

View full text Add to dashboard Cite

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an excellent analytical technique for rapid and sensitive analysis of macromolecules such as polymers and proteins. However, the main drawback of MALDI-TOF MS is its difficulty to detect small molecules with mass below 700 Da because of the intensive interference from MALDI matrix in the low mass region. In recent years there has been considerable interest in developing matrix-free laser desorption/ionization by using nanostructured substrates to substitute the conventional organic matrices, which is often referred as surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). Despite these attractive features, most of the current SALDI-TOF MS for the analysis of small molecules employ positive ion mode, which is subjected to produce multiple alkali metal adducts, and thus increases the complexity of the analysis. Different from the complicated adducts produced in positive ion mode, mass spectra obtained in negative ion mode are featured by deprotonated ion peaks without matrix interference, which simplifies the interpretation of mass spectra and detection of unknown. In this review, we critically survey recent advances in nanostructured substrates for negative ion LDI-TOF MS analysis of small molecules in the last 5 years. Special emphasis is placed on the preparation of the nanostructured substrates and the results achieved in negative ion SALDI-MS. In addition, a variety of promising applications including environmental, biological, and clinical analysis are introduced. The ionization mechanism of negative ionization is briefly discussed.

show abstract

Metal–organic frameworks: new matrices for surface-assisted laser desorption–ionization mass spectrometry

Cited by 75 publications

References 21 publications

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Performance of metal-organic framework MIL-101 after surfactant modification in the extraction of endocrine disrupting chemicals from environmental water samples

Negative ion laser desorption/ionization time‐of‐flight mass spectrometric analysis of small molecules by using nanostructured substrate as matrices

Contact Info

Product

Resources

About