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The organic extracts of two licorices, known in commerce as Russian and Xinjiang licorices, exhibited potent antimicrobial and antioxidant activity. The bioassay-directed chemical investigation of both licorices revealed glabrene, glabridin, and licochalcones A and B as active principles.

A new isoflavan was isolated from the root of Glycyrrhiza glabra (licorice; Fabaceae), and its stmcture was elucidated as 8-prenyl-phaseollinisoflavan on the basis of spectroscopic evidence. Five known isoflavans have also been isolated, and identified with glabridin, 4'-0-methylglabridin, hispaglabridins A, B and what was previously elucidated as "3'-methoxyglabridin". The structure of the latter compound was revised to 3'-hydroxy-4-0-methylglabridin by an irradiation experiment and long range I3C-'H COSY spectral analysis.

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