Antioxidant and antimicrobial constituents of licorice: Isolation and structure elucidation of a new benzofuran derivative.

Demizu, Sachio; Kajiyama, Kiichiro; Takahashi, Kunio; Hiraga, Yukio; Yamamoto, Susumu; Tamura, Yukiyoshi; Okada, Kazunari; Kinoshita, Takeshi

doi:10.1248/cpb.36.3474

Cited by 82 publications

(44 citation statements)

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“…Glycyrrhiza uralensis (9,19), Glycyrrhiza glabra (3,5,13,15,18,19), and Glycyrrhiza inflata (7,8,11,18,19), is currently used in the tobacco, food, and pharmaceutical industries. It has been used for centuries as a medicine because of its wide-ranging therapeutic properties, including relief of rheumatic and other pain, and its healing effect on gastric ulcers (19).…”

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confidence: 99%

Antibacterial Activity of Licochalcone A against Spore-Forming Bacteria

Tsukiyama¹,

Katsura²,

Tokuriki³

et al. 2002

Antimicrob Agents Chemother

123

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Licochalcone A was isolated from the roots of licorice, Glycyrrhiza inflata, which has various uses in the food and pharmaceutical industries; isolation was followed by extraction with ethanol and column chromatography with silica gel. In this study, the activities of licochalcone A against some food contaminant microorganisms were evaluated in vitro. The vegetative cell growth of Bacillus subtilis was inhibited in a licochalcone A concentration-dependent manner and was completely prevented by 3 g of licochalcone A/ml. Licochalcone A showed a high level of resistance to heating at 80 to 121°C for 15 min. Licochalcone A did not inhibit the germination of heat-treated spores of B. subtilis induced by L-alanine. Licochalcone A showed effects against all gram-positive bacteria tested and especially was effective against all Bacillus spp. tested, with MICs of 2 to 3 g/ml, but was not effective against gram-negative bacteria or eukaryotes at 50 g/ml. Although the cationic antimicrobial peptides protamine and -poly-L-lysine resulted in the loss of antimicrobial activity in the presence of either 3% (wt/vol) NaCl or protease at 20 g/ml, the antibacterial activity of licochalcone A was resistant to these conditions. Thus, licochalcone A could be a useful compound for the development of antibacterial agents for the preservation of foods containing high concentrations of salts and proteases, in which cationic peptides might be less effective.

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confidence: 99%

Antibacterial Activity of Licochalcone A against Spore-Forming Bacteria

Tsukiyama¹,

Katsura²,

Tokuriki³

et al. 2002

Antimicrob Agents Chemother

123

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“…Taking together all the above data, the PPAR-γ ligand-binding activity of the phenolic compounds was affected by slight differences in the substitution groups on the aromatic rings. were identified by comparison of their physical and spectral data with those of reported compounds as dehydroglyasperin C (41) [28], glyasperin D (42) [29], glycycoumarin (43) [30], glycyrin (44) [31], glyasperin B (45) [29], glycyrol (46) [32], isoglycyrol (47) [32], glicoricone (48) [33], licoricone (49) [34], licocoumarone (50) [30], gancaonin I (51) [35], and liquiritigenin (52) [36] (Figure 8). This was the first isolation of glyasperin B (45) from G. uralensis.…”

Section: Isolation and Structural Determination Of Phenolic Compoundsmentioning

confidence: 99%

Phenolics from Glycyrrhiza glabra and G. uralensis Roots and Their PPAR-γ Ligand-Binding Activity: Possible Application for Amelioration of Type 2 Diabetes

Kuroda¹,

Mimaki²

2017

Biological Activities and Action Mechanisms of Licorice Ingredients

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The EtOH extract of Glycyrrhiza glabra roots and the EtOAc extract of Glycyrrhiza uralensis roots exhibited considerable PPAR-γ ligand-binding activity. Bioassay-guided fractionation of these extracts resulted in the isolation of 52 phenolics, including 11 novel ones. The PPAR-γ ligand-binding activity of more than 10 isolated phenolics at 10 μg/mL was approximately three times greater than that of 0.5 μM triglitazone. Glycyrin (44), isolated from the EtOAc extract of G. uralensis roots as a PPAR-γ ligand, reduced the blood glucose levels of genetically diabetic KK-A y mice through its PPAR-γ ligand-binding activity.

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“…Licorice root, derived from the plant Glycyrrhiza glabra is used widely in Asia as a sweetener or a spice, contains flavonoids from the flavan and chalcone subclasses, and has a antioxidative properties [259]. Licorice-derived glabridin binds to the LDL particle and protects it from oxidation by its capacity to scavenge free radicals and its property to reduce the LDL aggregation [260,261].…”

Section: Licoricementioning

confidence: 99%