As novel wound dressings, cryogels with rapid hemostatic
property
and good sterilization effect are urgently desirable for wound healing.
To reduce the use of antibiotics, antibacterial photothermal therapy
with broad-spectrum bactericidal capacity and non-obvious bacterial
resistance has been widely researched. However, photothermal agents
usually suffer from poor hemostatic ability. In this research, sodium
alginate (SA) and epigallocatechin gallate (EGCG) were non-covalently
cross-linked in suit by ferric ions to obtain SA/EGCG/Fe
(SEF) cryogels after lyophilization as an antibacterial wound dressing.
Next, its photothermal performance was intensively assessed. Moreover,
its hemostasis and bactericidal effect were evaluated. First, it displayed
extraordinary photothermal ability owing to the formation of Fe3+/EGCG-based metal phenolic networks (MPNs) inside the SEF
cryogel. Furthermore, in vitro and in vivo assays illustrated that it exhibits rapid hemostatic capacity owing
to its high porosity and MPN-mediated cell adhesion capacity. In conclusion,
the SEF cryogel manifests satisfactory hemostatic and bactericidal
properties. Therefore, it is a promising wound-dressing candidate
for clinical applications.
To reduce the drug resistance of bacteria and enhance
the antibacterial
ability in bacterial infection therapy, we designed a new antibacterial
nanoagent. In this system, a photosensitizer (indocyanine green, ICG)
was loaded in bovine serum albumin (BSA) through hydrophobic-interaction-induced
self-assembly to form stable BSA@ICG nanoparticles. Furthermore, a
positively charged antibacterial peptide bacitracin (Bac) was physically
immobilized onto the surface of BSA@ICG to generate a bacterial-targeted
nanomedicine BSA@ICG@Bac through electrostatic interactions. Afterward,
its photodynamic and photothermal activities were intensely evaluated.
Moreover, its bactericidal efficiency was assessed
via
in vitro
antibacterial assays and bacterial biofilm
destruction tests. First, the obtained BSA@ICG@Bac showed both good
singlet oxygen generation property and high photothermal conversion
efficiency. In addition, it showed enhanced photodynamic and photothermal
antibacterial capacities and biofilm-removing ability
in vitro
due to Bac modification. To sum up, our research provided an economic
and less-time-consuming approach to preparing antibacterial nanomedicines
with excellent antibacterial ability. Therefore, the prepared antibacterial
nanomedicines have great potential to be utilized in clinical trials
in the future.
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