Photothermal nanoagent for anti-inflammation through macrophage repolarization following antibacterial therapy

Xu, Yueying; Cai, Yanjun; Yu, Xia; Wu, Quanxin; Li, Mingen; Guo, Ning; Tu, Yingfeng; Yang, Bin; Liu, Yun

doi:10.1016/j.eurpolymj.2023.111840

Cited by 8 publications

(6 citation statements)

References 57 publications

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“…The delivery of EGCG through this nanosystem enhanced the colloidal stability and biosafety of EGCG. Due to the release of EGCG, BSA@MPN repolarized M1 macrophages to M2 phenotype, which successfully achieved a satisfactory therapeutic effect of combined photothermal antimicrobial and anti-inflammatory treatment 70 (Figure 4A).…”

Section: Anti-inflammatorymentioning

confidence: 99%

“…136,138 As the most abundant polyphenol in green tea, EGCG has been reported to be a potent anti-inflammatory agent through the repolarization of macrophages from M1 to M2 phenotype. 70,139,140 Unfortunately, its poor bioavailability and rapid metabolism severely limit its application. To address this problem, Xu et al designed Fe 3+ /EGCG-based photothermite nanoparticles (BSA@MPN) by self-assembly of Fe 3+ and EGCG using BSA as a nanoreactor and colloidal stabilizer.…”

Section: Anti-inflammatorymentioning

confidence: 99%

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Metal–Phenolic Networks for Chronic Wounds Therapy

Wang,

Xing,

Zhang

et al. 2023

IJN

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Chronic wounds are recalcitrant complications of a variety of diseases, with pathologic features including bacterial infection, persistent inflammation, and proliferation of reactive oxygen species (ROS) levels in the wound microenvironment. Currently, the use of antimicrobial drugs, debridement, hyperbaric oxygen therapy, and other methods in clinical for chronic wound treatment is prone to problems such as bacterial resistance, wound expansion, and even exacerbation. In recent years, researchers have proposed many novel materials for the treatment of chronic wounds targeting the disease characteristics, among which metal-phenolic networks (MPNs) are supramolecular network structures that utilize multivalent metal ions and natural polyphenols complexed through ligand bonds. They have a flexible and versatile combination of structural forms and a variety of formations (nanoparticles, coatings, hydrogels, etc.) that can be constructed. Functionally, MPNs combine the chemocatalytic and bactericidal properties of metal ions as well as the anti-inflammatory and antioxidant properties of polyphenol compounds. Together with the excellent properties of rapid synthesis and negligible cytotoxicity, MPNs have attracted researchers' great attention in biomedical fields such as anti-tumor, anti-bacterial, and anti-inflammatory. This paper will focus on the composition of MPNs, the mechanisms of MPNs for the treatment of chronic wounds, and the application of MPNs in novel chronic wound therapies.

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Section: Anti-inflammatorymentioning

confidence: 99%

Section: Anti-inflammatorymentioning

confidence: 99%

Metal–Phenolic Networks for Chronic Wounds Therapy

Wang,

Xing,

Zhang

et al. 2023

IJN

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“…In Vitro and in vivo experiments specified the success rates and challenges of PTAs as antibiofilm agents. BSA@MPN + NIR treatment induced long-term varying degrees of bacterial membrane malformations and achieved >99% eradication of biofilms of S. aureus and E. coli [174]. Meanwhile, graphene and its derivatives, graphene oxide (GO) and reduced GO (rGO), due to their intrinsic properties and functionalisation with metal NPs, natural compounds, and antibiotics, could damage the bacterial morphology, release intracellular substances, and destroy the biofilm.…”

Section: Antibacterial Biofilmsmentioning

confidence: 99%

“…Furthermore, BSA@MPN, produced by Fe 3+ /EGCG-based self-assembly using BSA as the nanoreactor and colloidal stabiliser, possessed excellent photothermal-related bactericidal activity and macrophage M1-to-M2 phenotypic-conversion-related anti-inflammatory effects due to the photothermal properties and pH-responsive degradability of Fe 3+ /EGCG-based MPN. Next to biocompatibility and biosafety properties, in vitro and in vivo antibacterial and anti-inflammatory effects are imperative to wound healing [174].…”

Section: Cutaneous Woundsmentioning

confidence: 99%

Trends in Photothermal Nanostructures for Antimicrobial Applications

Dediu

Ghițman

Pîrcălăbioru

et al. 2023

IJMS

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The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries and the non-availability of novel antibiotics represents one of the most critical public health issues worldwide. Current advances in nanotechnology allow new materials to address drug-resistant bacterial infections in specific, focused, and biologically safe ways. The unique physicochemical properties, biocompatibility, and wide range of adaptability of nanomaterials that exhibit photothermal capability can be employed to develop the next generation of photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review the current state of the art in different functional classes of photothermal antibacterial nanomaterials and strategies to optimise antimicrobial efficiency. The recent achievements and trends in developing photothermally active nanostructures, including plasmonic metals, semiconductors, and carbon-based and organic photothermal polymers, and antibacterial mechanisms of action, including anti-multidrug-resistant bacteria and biofilm removal, will be discussed. Insights into the mechanisms of the photothermal effect and various factors influencing photothermal antimicrobial performance, emphasising the structure–performance relationship, are discussed. We will examine the photothermal agents’ functionalisation for specific bacteria, the effects of the near-infrared light irradiation spectrum, and active photothermal materials for multimodal synergistic-based therapies to minimise side effects and maintain low costs. The most relevant applications are presented, such as antibiofilm formation, biofilm penetration or ablation, and nanomaterial-based infected wound therapy. Practical antibacterial applications employing photothermal antimicrobial agents, alone or in synergistic combination with other nanomaterials, are considered. Existing challenges and limitations in photothermal antimicrobial therapy and future perspectives are presented from the structural, functional, safety, and clinical potential points of view.

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“…Therefore, this method can directly eliminate the bacteria in the infected part of the wound and promote wound healing. This treatment strategy is known as PTT [70], and the materials used are referred to as photothermal agents (PTAs) [71]. Depending on their source, common PTAs can be divided into three categories: inorganic Ptas (IPTAs) (four categories: metal materials [72][73][74], metal-oxide materials [75], metal-inorganic materials [76,77], and carbon-based materials [78,79]), organic PTA (OPTAs) [80], and organic-inorganic hybrid PTAs (O-I PTAs) [81].…”

Section: Photosensitive Antibacterial Complex Hydrogels Based On Pttmentioning

confidence: 99%

Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels

Wang

Liu

et al. 2023

Gels

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Hydrogels are materials consisting of a network of hydrophilic polymers. Due to their good biocompatibility and hydrophilicity, they are widely used in biomedicine, food safety, environmental protection, agriculture, and other fields. This paper summarizes the typical complex materials of photocatalysts, photosensitizers, and hydrogels, as week as their antibacterial activities and the basic mechanisms of photothermal and photodynamic effects. In addition, the application of hydrogel-based photoresponsive materials in microbial inactivation is discussed, including the challenges faced in their application. The advantages of photosensitive antibacterial complex hydrogels are highlighted, and their application and research progress in various fields are introduced in detail.

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Photothermal nanoagent for anti-inflammation through macrophage repolarization following antibacterial therapy

Cited by 8 publications

References 57 publications

Metal–Phenolic Networks for Chronic Wounds Therapy

Metal–Phenolic Networks for Chronic Wounds Therapy

Trends in Photothermal Nanostructures for Antimicrobial Applications

Controllable Preparation and Research Progress of Photosensitive Antibacterial Complex Hydrogels

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