α-Fe2O3 based nanotherapeutics for near-infrared/dihydroartemisinin dual-augmented chemodynamic antibacterial therapy

Xu, Yueying; Xiao, Le; Chen, Jia; Wu, Quanxin; Yu, Wenhua; Zeng, Weishen; Shi, Yaxin; Lu, Yingnian; Liu, Yun

doi:10.1016/j.actbio.2022.07.047

Cited by 35 publications

(37 citation statements)

References 47 publications

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“…The heating process and data collection were performed as previously described. Photothermal conversion efficiency was calculated according to previous reports …”

Section: Methodsmentioning

confidence: 99%

“…Photothermal conversion efficiency was calculated according to previous reports. 41 2.9. Bacteria Culture.…”

Section: Preparation Of Thementioning

confidence: 99%

“…Due to the inherent deep penetration, noninvasiveness, and local site targeting properties, the near-infrared (NIR)-responsive photothermal therapy (PTT) offers a promising alternative for antibacterial wound dressing fabrication. − Photothermal-active materials such as metallic compounds, carbon nanomaterials, and organic dye have been completely studied for biomedical treatments. − However, their applied exploration is limited by the high cost, tedious synthesis, low biocompatibility, and low biodegradation. Recently, metal-phenolic networks (MPNs) have been well studied to serve as a PTT platform owing to low cost and good biocompatibility. − The fabrication of MPNs was mainly based on the chelation between metal ions and the catechol structure. It suggests that the utilization of polyphenol compounds and metal ions may offer an approach to the development of new photothermal materials.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, metal-phenolic networks (MPNs) have been well studied to serve as a PTT platform owing to low cost and good biocompatibility. 39 − 41 The fabrication of MPNs was mainly based on the chelation between metal ions and the catechol structure. It suggests that the utilization of polyphenol compounds and metal ions may offer an approach to the development of new photothermal materials.…”

Section: Introductionmentioning

confidence: 99%

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Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis

et al. 2023

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As novel wound dressings, cryogels with rapid hemostatic property and good sterilization effect are urgently desirable for wound healing. To reduce the use of antibiotics, antibacterial photothermal therapy with broad-spectrum bactericidal capacity and non-obvious bacterial resistance has been widely researched. However, photothermal agents usually suffer from poor hemostatic ability. In this research, sodium alginate (SA) and epigallocatechin gallate (EGCG) were non-covalently cross-linked in suit by ferric ions to obtain SA/EGCG/Fe (SEF) cryogels after lyophilization as an antibacterial wound dressing. Next, its photothermal performance was intensively assessed. Moreover, its hemostasis and bactericidal effect were evaluated. First, it displayed extraordinary photothermal ability owing to the formation of Fe3+/EGCG-based metal phenolic networks (MPNs) inside the SEF cryogel. Furthermore, in vitro and in vivo assays illustrated that it exhibits rapid hemostatic capacity owing to its high porosity and MPN-mediated cell adhesion capacity. In conclusion, the SEF cryogel manifests satisfactory hemostatic and bactericidal properties. Therefore, it is a promising wound-dressing candidate for clinical applications.

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“…The heating process and data collection were performed as previously described. Photothermal conversion efficiency was calculated according to previous reports …”

Section: Methodsmentioning

confidence: 99%

“…Photothermal conversion efficiency was calculated according to previous reports. 41 2.9. Bacteria Culture.…”

Section: Preparation Of Thementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis

et al. 2023

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“…Due to the presence of more than one metal, these nanoalloys can produce Fenton and peroxidase-like reactions for inhibiting infection. 66,67 Similarly, bi-metallic nanostructures have also been exploited by several groups to inhibit bacterial infection by using PTT. For instance, Sun et al devised a bimetallic nanosheet composed of FeS@ Cu 2 O to minimize the hyperthermia-mediated damage during PTT.…”

Section: Nanomaterials As Multimodal Ptasmentioning

confidence: 99%

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Roy

Guo

2023

J. Mater. Chem. B

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Remodeling Microenvironment for Implant‐Associated Osteomyelitis by Dual Metal Peroxide

Guan,

Wu,

Ouyang

et al. 2024

Adv Healthcare Materials

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Implant‐associated osteomyelitis (IAOM) is characterized by deep bone infection and progressive bone destruction, current therapy of long‐term high‐dose antibiotic treatment and radical surgical debridement often results in drug‐resistance and large bone defect. It is highly challenging to develop an antibiotic‐free, rapid bactericidal and osteogenic‐enhanced strategy for IAOM. Herein, we design an IAOM tailored anti‐bacterial and osteoinductive composite of Cu‐Sr peroxide nanoparticles (CSp NPs) encapulated in polyethylene glycol diacrylate (PEGDA) (CSp@PEGDA). The dual functional CSp NPs spontaneously displays in situ H2O2 self‐supplying and Fenton‐catalytic Cu2+ ions release, generating plenty of highly toxic hydroxyl radical (·OH) in a pH‐responsive manner for bacterial killing, while the released Sr2+ promotes the in vitro osteogenicity regarding cell proliferation, alkaline phosphatase activity, extracellular matrix calcification, and osteo‐associated genes expression. The integration of Cu2+ and Sr2+ in synthesized CSp NPs together with the coated PEGDA hydrogel ensures the stable and sustainable ions release during short‐ and long‐term periods. Benefitted from the injectablity and photo‐crosslinkability, CSp@PEGDA is able to thoroughly fill the infectious site and rapidly gelate in situ for bacterial elimination and bone regeneration, which is successfully verified through in vivo evaluation using a clinical‐simulating IAOM mouse model. These favorable abilities of CSp@PEGDA precisely meet the multiple therapeutic needs and pave a promising way for implant‐associated osteomyelitis treatment.This article is protected by copyright. All rights reserved

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α-Fe2O3 based nanotherapeutics for near-infrared/dihydroartemisinin dual-augmented chemodynamic antibacterial therapy

Cited by 35 publications

References 47 publications

Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis

Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis

Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’

Remodeling Microenvironment for Implant‐Associated Osteomyelitis by Dual Metal Peroxide

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