Thalassemia adalah penyakit kronik yang menyebabkan penurunan Hb karena gangguan sintesis hemoglobin akibat mutasi satu atau lebih gen globin. Thalassemia dapat menyebabkan gangguan status gizi. Status gizi penderita thalassemia dipengaruhi oleh keadaan anemia kronik, kelebihan zat besi akibat rendahnya kepatuhan minum obat kelasi besi yang rendah, usia saat terdiagnosis, kadar Hb saat akan dilakukan transfusi, nutrisi dan penyakit penyerta. Tujuan penelitian ini mengetahui hubungan antara kadar hemoglobin dan status gizi pada penderita thalassemia-β mayor di RSUD Al Ihsan Provinsi Jawa Barat. Penelitian ini menggunakan metode analitik dengan melihat data rekam medis pasien Thalassemia-β mayor di Klinik Anak RSUD Al-Ihsan periode Maret - Juni 2020 dengan rancangan studi cross sectional. Kriteria inklusi: usia 0 - 18 tahun, terdapat data BB, TB dan Hb. Dari 92 anak yang menderita Thalassemia-β mayor terdapat 82 anak yang memenuhi kriteria inklusi, kebanyakan berusia 1 - 5 tahun (40%) dengan jenis kelamin laki-laki 43 anak dan perempuan 39 anak. Pada anak usia ≤ 5 tahun: 85% status gizinya normal, gizi kurang 6%, perawakan normal 67%, perawakan pendek 18%, dan perawakan sangat pendek 15%. Anak usia > 5 tahun: 71% status gizinya normal, gizi kurus 10%, sangat kurus hanya 2%, perawakan normal 35%, perawakan pendek 43%, dan perawakan sangat pendek 22%. Nilai-p BB/TB pada anak ≤ 5 tahun yaitu 0.494 dan TB/U 0.33. Pada anak usia > 5 tahun dihasilkan nilai-p IMT/U 0,595 dan TB/U 0,230. Simpulan penelitian adalah kadar hemoglobin tidak memiliki hubungan dengan status gizi pasien Thalassemia-β mayor. The Relationship between Hemoglobin Levels and Nutritional Status in Thalassemia B Major Patients in Al Ihsan Hospital West Java ProvinceThalassemia is chronic disease that causes decrease in Hb due to hemoglobin synthesis disorders. Thalassemia can cause nutritional status disorders. Factors that influence nutritional status are age at diagnosis, Hb level at the time of transfusion, chronic anemia, iron overload due to low adherence to taking iron chelating agent drugs, nutrition and comorbidities. The purpose of this study is to see the relationship between hemoglobin levels and nutritional status in thalassemia B major patients in Al Ihsan Hospital West Java province. Using the analytic method by looking at the medical record data of patients who went to the children’s clinic at Al Ihsan Hospital during the March - June 2020 period with a cross-sectional study. The inclusion criteria were children aged 0 - 18 years and there were data on body weight, height and Hb level. Of the 92 thalassemia patients, 82 met the inclusion criteria. Mostly aged 1-5 years (40%) with male 43 children and female 39 children. Children aged < 5 years: 85% normal nutritional status, 6% wasted, 67% normal stature, 18% stunted and 15% severely stunted, with p-value W/BH was 0.493 and p-value BH/A was 0.331. Children > 5 years aged: 71% normal nutritional status, 10% wasted, 2% severely wasted, 35% normal stature, 43% stunted and 22% severely stunted, with p-value BMI/A was 0.595 and p-value BH/A was 0.230. The conclusion of this study is there is no relationship between hemoglobin levels and nutritional status in thalassemia B major patients.
Background Arterial blood gas is usually beneficial to discern thenature of gas exchange disturbances, the effectiveness of com-pensation, and is required for adequate management. AlthoughPaO 2 is the standard measurement of blood oxygenation, oxygensaturation measured by pulse oximetry (SapO 2 ) is now a custom-ary noninvasive assessment of blood oxygenation in newborn in-fants.Objective To compare oxygen saturation measured by pulse oxi-metry (SapO 2 ) and arterial blood gas (SaO 2 ), its correlation withother variables, and to predict arterial partial pressure of oxygen(PaO 2 ) based on SapO 2 values.Methods A cross sectional study was conducted on all neonatesadmitted to Pediatric Intensive Care Unit (PICU) during February2001 to May 2002. Neonates were excluded if they had impairedperipheral perfusion and/or congenital heart defects. Paired t-testwas used to compare SapO 2 with SaO 2 . Correlation between twoquantitative data was performed using Pearson’s correlation. Re-gression analysis was used to predict PaO 2 based on SapO 2 val-ues.Results Thirty neonates were included in this study. The differ-ence between SaO 2 and SapO 2 was significant . There were sig-nificant positive correlations between heart rate /pulse rate andTCO 2 , HCO 3 ; respiratory rate and TCO 2 , HCO 3 , base excess (BE);core temperature and HCO 3 , BE; surface temperature and pH,TCO 2, HCO 3, BE; SapO 2 and pH, PaO 2 ; and significant negativecorrelation between SapO 2 and PaCO 2 ; the correlations were weak.The linear regression equation to predict PaO 2 based on SapO 2values was PaO 2 = -79.828 + 1.912 SapO 2 .Conclusion Pulse oximetry could not be used in place of arterialblood gas analysis available for clinical purpose
Angka morbiditas dan mortalitas akibat penyakit diare didunia masih sangat tinggi terutama pada negara berkembang. Diare merupakan penyebab kematian ke-4 pada golongan semua umur di Indonesia, serta angka morbiditasnya menempati urutan ke-5 di Kota Bandung. Faktor risiko terjadinya diare berkaitan dengan program Perilaku Hidup Bersih dan Sehat (PHBS). Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan antara PHBS dengan kejadian diare akut pada siswa kelas VIII SMP Plus Pesantren Baiturrahman Bandung. Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross sectional. Subjek terdiri dari 140 responden, secara consecutive sampling. Pengambilan data menggunakan kuesioner yang berisi pertanyaan mengenai PHBS tatanan intitusi pendidikan serta kejadian diare akut. Uji statistik menggunakan chi square. Hasil penelitian didapatkan lebih banyak responden yang tidak melakukan PHBS (55%) dibandingkan responden yang melakukan PHBS (45%). Sebagian besar tidak mengalami diare akut (75%) dan sebagian kecil mengalami diare akut (25%). Hasil penelitian ini memperlihatkan terdapat hubungan antara PHBS dengan kejadian diare akut pada siswa kelas VIII SMP Plus Pesantren Baiturrahman Bandung (p value = 0,001). Penelitian ini menunjukan pentingnya praktik PHBS pada lingkup siswa SMP.
Objective To examine hemolysis in falciparum and vivax malarialpatients based on serum bilirubin examination.Methods A cross sectional study was conducted on childrenyounger than 15 years of age who visited public health center inthe district of Mandailing Natal with complaints of fever, shivering,pale, jaundice, diarrhea, or headache between April 9 th and April19 th 2001. Variables recorded were age, gender, body weight, bodyheight, symptoms and signs, anti malarial drugs, and laboratorytest results. Thin and thick blood smears were done as diagnostictools of malaria. Thin blood smear was also performed to deter-mine the level of malaria parasites in blood (parasitemia) and toexamine the morphology of red blood cells. Hemolysis was deter-mined by bilirubin examination.Results In P. falciparum malaria, there was a moderate correlation(r=0.68, p<0.0001) between parasitemia and indirect bilirubin con-centration. While in P. vivax malaria, there was only a weak corre-lation (r=0.46, p=0.007) between parasitemia and indirect bilirubinconcentration. It was also found that in falciparum malaria, para-sitemia, total and indirect bilirubin concentrations were significantlyhigher than that in vivax malaria, with p values of 0.009, 0.015 and0.003, respectively.Conclusion Hemolysis in falciparum malaria is more severe thanthat in P. vivax malaria, with marked elevation of indirect bilirubin.The elevation of serum bilirubin correlated with parasitemia
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