Neonatal asphyxia can cause renal perfusion and dilution disorders and also glomerular filtration abnormality. The purpose of this study was to find renal dysfunction, which caused by neonatal asphyxia. The study was performed by cross sectional for newborn babies with asphyxia based on Apgar score in the first minute. Newborn babies without asphyxia were as control. In both group, the first micturition times were recorded, total urine output in 24 hours were counted, the mean of blood urea and creatinine serum level value examined and also glomerular filtration rate. Statistical analysis has been performed by using Fisher Exact test, Student t test and Wilcoxon Rank Sum test. All of babies in the asphyxiated and non asphyxiated group had the first micturition in 24 hours after delivery. Significant difference of oliguria incidence was found in the asphyxiated group compared to the control group (p<0,05). The mean of blood urea and creatinine serum level was significantly higher in asphyxiated (p<0,05). The mean of glomerular filtration rate in the asphyxiated group was not significantly different to the control group (p>0,05). According to the degree of asphyxia we found significantly different of renal dysfunction (p<0,05). It was concluded that the asphyxia could cause the occurrence of renal dysfunction.
Background Arterial blood gas is usually beneficial to discern thenature of gas exchange disturbances, the effectiveness of com-pensation, and is required for adequate management. AlthoughPaO 2 is the standard measurement of blood oxygenation, oxygensaturation measured by pulse oximetry (SapO 2 ) is now a custom-ary noninvasive assessment of blood oxygenation in newborn in-fants.Objective To compare oxygen saturation measured by pulse oxi-metry (SapO 2 ) and arterial blood gas (SaO 2 ), its correlation withother variables, and to predict arterial partial pressure of oxygen(PaO 2 ) based on SapO 2 values.Methods A cross sectional study was conducted on all neonatesadmitted to Pediatric Intensive Care Unit (PICU) during February2001 to May 2002. Neonates were excluded if they had impairedperipheral perfusion and/or congenital heart defects. Paired t-testwas used to compare SapO 2 with SaO 2 . Correlation between twoquantitative data was performed using Pearson’s correlation. Re-gression analysis was used to predict PaO 2 based on SapO 2 val-ues.Results Thirty neonates were included in this study. The differ-ence between SaO 2 and SapO 2 was significant . There were sig-nificant positive correlations between heart rate /pulse rate andTCO 2 , HCO 3 ; respiratory rate and TCO 2 , HCO 3 , base excess (BE);core temperature and HCO 3 , BE; surface temperature and pH,TCO 2, HCO 3, BE; SapO 2 and pH, PaO 2 ; and significant negativecorrelation between SapO 2 and PaCO 2 ; the correlations were weak.The linear regression equation to predict PaO 2 based on SapO 2values was PaO 2 = -79.828 + 1.912 SapO 2 .Conclusion Pulse oximetry could not be used in place of arterialblood gas analysis available for clinical purpose
Distres pernapasan merupakan salah satu problem yang mengancam jiwa. Analisis gasdarah arteri (AGDA) penting untuk menentukan tata laksana distres pernapasan, sepertimenegakkan diagnosis, menentukan terapi, maupun untuk evaluasi setelah mendapatterapi. Namun interpretasinya harus dilakukan bersamaan dengan penilaian klinis.Kelainan AGDA oleh karena gangguan pernapasan dapat berupa asidosis respiratorik(pada gangguan paru restriktif), alkalosis respiratorik (pada gangguan paru obstruktif)dan asidosis campuran (pada penyakit paru dengan komplikasi). Prinsip umum tatalaksana distres pernapasan ditujukan kepada penyakit utamanya. Perhatian harusditujukan pada perbaikan volume ekstraselular, koreksi elektrolit, menghilangkan zattoksik, dan memperbaiki ventilasi.
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