The effect of neonatal asphyxia on renal function

Abstract

Neonatal asphyxia can cause renal perfusion and dilution disorders and also glomerular filtration abnormality. The purpose of this study was to find renal dysfunction, which caused by neonatal asphyxia. The study was performed by cross sectional for newborn babies with asphyxia based on Apgar score in the first minute. Newborn babies without asphyxia were as control. In both group, the first micturition times were recorded, total urine output in 24 hours were counted, the mean of blood urea and creatinine serum level value examined and also glomerular filtration rate. Statistical analysis has been performed by using Fisher Exact test, Student t test and Wilcoxon Rank Sum test. All of babies in the asphyxiated and non asphyxiated group had the first micturition in 24 hours after delivery. Significant difference of oliguria incidence was found in the asphyxiated group compared to the control group (p<0,05). The mean of blood urea and creatinine serum level was significantly higher in asphyxiated (p<0,05). The mean of glomerular filtration rate in the asphyxiated group was not significantly different to the control group (p>0,05). According to the degree of asphyxia we found significantly different of renal dysfunction (p<0,05). It was concluded that the asphyxia could cause the occurrence of renal dysfunction.

Study of Renal Profile in Babies with Perinatal Asphyxia in a Tertiary Care Hospital: A Prospective Case Control Study

“…Asphyxia at patho-physiological level, is the simultaneous combination of both hypoxia and hypoperfusion which impairs tissue gas exchange leading to tissue acidosis. Perinatal asphyxia will occur due to gas exchange and oxygen transportation disorders at birth that result lack of oxygen supply and diffi culties in carbon -di-oxide expiration 3 . This lack of oxygen supply in brain gives rise to hypoxic ischaemic injury to central nervous system; the clinical manifestation of this injury is termed as hypoxic ischaemic encephalopathy.…”

“…Cardiac output attempt to maintain blood fl ow to vital organ as heart, central nervous system, and also reduce blood fl ow to another organ like kidney, gastrointestinal and the other peripheral organ 3 . Almost any organ can be affected, but the brain, myocardium, kidneys and bowel appears to be most sensitive to severe damage 4 .…”