Sharper image: A newly developed polysaccharide/drug conjugate (see picture) responds to changes in pH value and was shown to penetrate HeLa tumors in mice as determined by fluorescence imaging. It has the potential to be used in photodynamic therapy, thereby targeting the tumor while having no detrimental effects on the surrounding tissue.
Solid pseudopapillary tumor of the pancreas is a rare neoplasm usually found in young women. Typical solid pseudopapillary tumor is characterized by a well-encapsulated mass with varying amounts of intratumoral hemorrhage. However, the tumor can have an atypical appearance, such as metastasis, ductal obstruction, parenchymal and extracapsular invasion, simulation of islet cell tumor, intratumoral calcification, and occurrence in a male patient. The typical and atypical manifestations of solid pseudopapillary tumor can be visualized with cross-sectional imaging.
Trojanisches Pferd: Ein neu entwickeltes Polysaccharid‐Wirkstoff‐Konjugat (siehe Bild) reagiert auf Änderungen des pH‐Werts und kann in HeLa‐Mäusetumoren eindringen, wie durch Fluoreszenzbildgebung gezeigt wurde. Das Konjugat hat Anwendungspotenzial in der photodynamischen Therapie: Es greift gezielt den Tumor an, ohne das umgebende Gewebe zu schädigen.
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
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