A Smart Polysaccharide/Drug Conjugate for Photodynamic Therapy

Park, So Young; Baik, Hye Jung; Oh, Young-Jin; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong

doi:10.1002/anie.201006038

Cited by 240 publications

(295 citation statements)

References 11 publications

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“…Finally, it should deliver the photosensitizer in the monomeric form in order to avoid the decrease in singlet oxygen quantum yield caused by aggregation [163]. have recently included activatable photosensitizer-polymer conjugates, self-quenchable nanoparticles and polymer-PS-quencher nanocomplex into the active delivery systems [163,[170][171][172]. This class of carriers can deliver the PS in a photodynamically inactive form and induce the phototoxicity directly at the tumor site and thus reduce the associated side effects [173].…”

Section: Immobilized Systems: Photosensitizers Delivery Carriersmentioning

confidence: 98%

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dąbrowski

Pucelik

Regiel-Futyra

et al. 2016

Coordination Chemistry Reviews

236

197

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Section: Immobilized Systems: Photosensitizers Delivery Carriersmentioning

confidence: 98%

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Dąbrowski

Pucelik

Regiel-Futyra

et al. 2016

Coordination Chemistry Reviews

236

197

View full text Add to dashboard Cite

“…The intention is to rely on the ability of the targeting vehicle to control localization so that the PS can be chosen based on its photochemical properties rather than on its tumour targeting properties, which are often unimpressive. These targeting vehicles include monoclonal antibodies [74], antibody fragments [75], peptides [76], proteins such as transferrin [77], epidermal growth factor [77] and insulin [78], LDL [79], various carbohydrates [80], somatostatin [81], folic acid [82] and many others. Table 4 lists some of these targeting ligand–PS conjugates.…”

Section: Targeted Pdtmentioning

confidence: 99%

New photosensitizers for photodynamic therapy

Abrahamse

Hamblin

2016

Biochemical Journal

1,521

1,172

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Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic dyes) that are activated by absorption of visible light to initially form the excited singlet state, followed by transition to the long-lived excited triplet state. This triplet state can undergo photochemical reactions in the presence of oxygen to form reactive oxygen species (including singlet oxygen) that can destroy cancer cells, pathogenic microbes and unwanted tissue. The dual-specificity of PDT relies on accumulation of the PS in diseased tissue and also on localized light delivery. Tetrapyrrole structures such as porphyrins, chlorins, bacteriochlorins and phthalocyanines with appropriate functionalization have been widely investigated in PDT, and several compounds have received clinical approval. Other molecular structures including the synthetic dyes classes as phenothiazinium, squaraine and BODIPY (boron-dipyrromethene), transition metal complexes, and natural products such as hypericin, riboflavin and curcumin have been investigated. Targeted PDT uses PSs conjugated to antibodies, peptides, proteins and other ligands with specific cellular receptors. Nanotechnology has made a significant contribution to PDT, giving rise to approaches such as nanoparticle delivery, fullerene-based PSs, titania photocatalysis, and the use of upconverting nanoparticles to increase light penetration into tissue. Future directions include photochemical internalization, genetically encoded protein PSs, theranostics, two-photon absorption PDT, and sonodynamic therapy using ultrasound.

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“…Similar phenomenon was observed with polymer-conjugated pH-responsive sensitizers. 11 These issues may adversely affect therapeutic selectivity and should be taken into consideration for the practical application of pH-responsive sensitizers. Comparing to the pH-dependent Φ Δ (Figure 5), a significant drop in cell viability was not obtained when pH was decreased from 7.4 to 6.0.…”

Section: Resultsmentioning

confidence: 99%

Enhanced photodynamic selectivity of nano-silica-attached porphyrins against breast cancer cells

Fan

et al. 2012

J. Mater. Chem.

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The synthesis and characterization of bare silica (4 nm in diameter) nanoparticle-attached meso-tetra(N-methyl-4-pyridyl)porphine (SiO2-TMPyP, 6 nm in diameter) are described for pH-controllable photosensitization. Distinguished from organosilanes, SiO2 nanoparticles were functionalized as a potential quencher of triplet TMPyP and/or singlet oxygen (1O2) at alkaline pH, thereby turning off sensitizer photoactivity. In weak acidic solutions, TMPyP was released from SiO2 surface for efficient production of 1O2. By monitoring 1O2 luminescence at 1270 nm, quantum yields of 1O2 production were found to be pH-dependent, dropping from ~ 0.45 in a pH range of 3–6 to 0.08 at pH 8–9, which is consistent with pH-dependent adsorption behavior of TMPyP on SiO2 surface. These features make bare SiO2-attached cationic porphyrin a promising candidate for use in PDT for cancer treatment in which efficient 1O2 production at acidic pH and sensitizer deactivation at physiological pH are desirable. The enhanced therapeutic selectivity was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests and trypan blue exclusion tests of cell viability in breast cancer cell lines. Bimolecular quenching rate constants of 1O2 by free TMPyP, SiO2 and SiO2-TMPyP nanoparticles were also determined.

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A Smart Polysaccharide/Drug Conjugate for Photodynamic Therapy

Cited by 240 publications

References 11 publications

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

Engineering of relevant photodynamic processes through structural modifications of metallotetrapyrrolic photosensitizers

New photosensitizers for photodynamic therapy

Enhanced photodynamic selectivity of nano-silica-attached porphyrins against breast cancer cells

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