Binary mixing of micelles using Pluronics for a nano-sized drug delivery system

Lee, Eun Seong; Oh, Young-Jin; Youn, Yu Seok; Nam, Myounghwa; Park, Byungtae; Yun, Jungmin; Kim, Ji Hoon; Song, Ho Taek; Oh, Kyung Taek

doi:10.1016/j.colsurfb.2010.08.033

Cited by 109 publications

(79 citation statements)

References 26 publications

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“…These micelles can show spherical, cylindrical or lamellar morphology. This depends on the relative length of both blocks, which changes the hydrophilic-lipophilic balance (HLB) of block copolymers [7,8,10,11] . Due to their small particle size (<100 nm) these systems exhibit many advantages such as targeting ability, long circulation time and easy production on effective delivery of drugs.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, self-assembly copolymer surfactants have been used as solubilizing and stabilizing agents of poorly water soluble drugs in pharmaceutical formulations [1][2][3][4][5] . These polymers form micelles in aqueous solution with a core/shell architecture, where the hydrophobic core is segregated from the aqueous exterior by a hydrophilic shell, which provide themselves an effective drug carrier [3,[6][7][8][9] . Among these systems, amphiphilic triblock copolymers formed by poly(ethylene oxide) (E) and poly(propylene oxide) (P) blocks with an E M P N E M arrangement (where "m" and "n" denote the monomers units) have been studied.…”

Section: Introductionmentioning

confidence: 99%

“…Therewith, Lee et al [8] studied binary mixtures with similar length of hydrophobic block which these E M P N E M copolymers are chosen as nanocarriers for encapsulation of hydrophobic drugs in order to combine the advantages in their physicochemical properties such as a high colloidal stability, formation of small particle size, good solubilisation capacity and thermally reversible gelation behavior [8,10,11] .…”

Section: Introductionmentioning

confidence: 99%

“…Due to their small particle size (<100 nm) these systems exhibit many advantages such as targeting ability, long circulation time and easy production on effective delivery of drugs. Incorporation of low molecular mass drugs into Pluronic  micelles can increase their solubility and stability and improve their pharmacokinetics and biodistribution [7][8][9][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

“…Although the hydrophobic griseofulvin was used as a standard drug to compare the values of S CP of the copolymers and their mixture, recently, griseofulvin has been attracting considerable interest as a potential anticancer drug, that shows low toxicity and efficacy to kill cancer cells [6,8,16,17] . In addition, studies such as micellar properties, i.e., critical micelle concentration (CMC) and particle size as micelle hydrodynamic diameter (D H ), are necessaries to confirm their values of S CP , and verified their stability as hydrophobic drug deliveries at body temperature [1,10,11,13,18] .…”

Section: Introductionmentioning

confidence: 99%

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Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

et al. 2015

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Sbstract Pluronics molecules self-assemble in aqueous solution providing a core/shell architecture that improves the solubility of hydrophobic drugs. Binary mixtures of Pluronics  have been studied as drug nanocarriers in order to combine their advantages, like high colloidal stability, small particle size and good solubilisation capacity (S cp ). In this work we studied Pluronics  binary mixture, P123 and F127, as nanocarriers of the hydrophobic drug griseofulvin. P123 (E 21 P 67 E 21 ) shows a relative good S cp , whereas F127 (E 98 P 67 E 98 ) shows a good colloidal stability. According to data, these binary mixtures form stables nano-sized comicelles in aqueous solution. The S cp of the P123/F127 systems at 25 and 37 °C was monitored by UV/Visible spectroscopy, showing good results at both temperatures, as would be expected, since P123/F127 have similar length hydrophobic block. Hydrophobic-dependence and temperature-responsive of the systems were evaluated by CMC, particle size and colloidal stability. Hence, stables P123/F127 comicelles may have potencial as hydrophobic drug delivery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

et al. 2015

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Shell Cross‐Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti‐HCV Therapy

Jiménez-Pardo

González-Pastor

Lancelot

et al. 2015

Macromolecular Bioscience

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A suitable carrier for camptothecin to act as therapy against the hepatitis C virus is presented. The carrier relies on an amphiphilic hybrid dendritic-linear-dendritic block copolymer, derived from pluronic F127 and bis-MPA dendrons, that forms micelles in aqueous solution. The dendrons admit the incorporation of multiple photoreactive groups that allow the clean and effective preparation of covalently cross-linked polymeric micelles (CLPM), susceptible of loading hydrophilic and lipophilic molecules. Cell-uptake experiments using a newly designed fluorophore, derived from rhodamine B, demonstrate that the carrier favors the accumulation of its cargo within the cell. Furthermore, loaded with camptothecin, it is efficient in fighting against the hepatitis C virus while shows lower cytotoxicity than the free drug.

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Hyperspectral microscopy as an analytical tool for nanomaterials

Roth

Tahiliani

Neu‐Baker

et al. 2015

WIREs Nanomed Nanobiotechnol

101

111

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Hyperspectral microscopy is an advanced visualization technique that combines hyperspectral imaging with state-of-the-art optics and computer software to enable the rapid identification of materials at the micro- and nanoscales. Achieving this level of resolution has traditionally required time-consuming and costly electron microscopy techniques. While hyperspectral microscopy has already been applied to the analysis of bulk materials and biologicals, it shows extraordinary promise as an analytical tool to locate individual nanoparticles and aggregates in complex samples through rapid optical and spectroscopic identification. This technique can be used to not only screen for the presence of nanomaterials, but also to locate, identify, and characterize them. It could also be used to identify a subset of samples that would then move on for further analysis via other advanced metrology. This review will describe the science and origins of hyperspectral microscopy, examine current and emerging applications in life science, and examine potential applications of this technology that could improve research efficiency or lead to novel discoveries.

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Binary mixing of micelles using Pluronics for a nano-sized drug delivery system

Cited by 109 publications

References 26 publications

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation

Shell Cross‐Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti‐HCV Therapy

Hyperspectral microscopy as an analytical tool for nanomaterials

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