A novel pH-responsive polysaccharidic ionic complex for proapoptotic d-(KLAKLAK)2 peptide delivery

Lee, Bo Reum; Oh, Kyung Taek; Oh, Young-Jin; Baik, Hye Jung; Park, So Young; Youn, Yu Seok; Lee, Eun Seong

doi:10.1039/c0cc03590d

Cited by 42 publications

(58 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30μM caused 60% mortality of HeLa cells), increasing the biological activity of the peptide [126]. The formation of a pH-responsive nanocomplex consisting of GCS-g-DMA (glycol chitosan graft with 2,3-dimethylmaleic acid) and KLA peptide resulted in release of the KLA peptide in response to increasing acidic pH, and the accumulation of the KLA peptide in murine tumors [127]. In order to produce a nanosystem to target tumor vasculature, the KLA peptide was fused to a TTP (CGKRK peptide) and multivalent presentation achieved using iron oxide nanoparticles.…”

Section: Cell-penetrating and Tumor-targeting Peptidesmentioning

confidence: 99%

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

Boohaker¹,

Lee²,

Vishnubhotla³

et al. 2012

CMC

285

219

View full text Add to dashboard Cite

Peptide therapeutics is a promising field for emerging anti-cancer agents. Benefits include the ease and rapid synthesis of peptides and capacity for modifications. An existing and vast knowledge base of protein structure and function can be exploited for novel peptide design. Current research focuses on developing peptides that can (1) serve as tumor targeting moieties and (2) permeabilize membranes with cytotoxic consequences. A survey of recent findings reveals significant trends. Amphiphilic peptides with clusters of hydrophobic and cationic residues are features of anti-microbial peptides that confer the ability to eradicate microbes and show considerable anti-cancer toxicity. Peptides that assemble and form pores can disrupt cell or organelle membranes and cause apoptotic or necrotic death. Cell permeable and tumor-homing peptides can carry biologically active cargo to tumors or tumor vasculature. The challenge lies in developing the clinical application of therapeutic peptides. Improving delivery to tumors, minimizing non-specific toxic effects and discerning pharmacokinetic properties are high among the needs to produce a powerful therapeutic peptide for cancer treatment.

show abstract

Section: Cell-penetrating and Tumor-targeting Peptidesmentioning

confidence: 99%

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

Boohaker¹,

Lee²,

Vishnubhotla³

et al. 2012

CMC

285

219

View full text Add to dashboard Cite

show abstract

“…A DMA-conjugated primary amine can be changed to free primary amine at a slightly acidic pH (~pH 6.8) due to the detachment of DMA via the rapid hydrolysis of the weak-acid linkage, as we previously demonstrated. 13,14 As a result, the inclusion complex nano-vehicles can be destabilized in an acidic milieu (e.g. human tumor extracellular pH: ~6.8) 15,[20][21][22] (Figure 1(b)).…”

Section: Resultsmentioning

confidence: 99%

A molecular zipping/unzipping nano-vehicles sensitive to tumor extracellular pH

Lee

Kim

et al. 2014

Journal of Bioactive and Compatible Polymers

Self Cite

View full text Add to dashboard Cite

A new class of pH-responsive multivalent host-guest interactions to manipulate polypeptidebased nano-vehicles was developed. Poly(l-lysine) (poly(Lys)) grafted with β-cyclodextrin and 2,3-dimethylmaleic acid was coupled with oleic acid. This new polymer was utilized to fabricate pH-responsive nano-vehicles for antitumor drug doxorubicin delivery. The host-guest (zipping) interaction between β-cyclodextrin and 2,3-dimethylmaleic acid moieties and the hydrophobic interaction between the oleic acid molecules contributed to form self-assembled nano-vehicles. 2,3-Dimethylmaleic acid moieties were highly degradable at a slightly acidic pH (~pH 6.8). These nano-vehicles increased the release of the encapsulated doxorubicin content (by the unzipping interaction between β-cyclodextrin and degraded 2,3-dimethylmaleic acid moieties) when the pH of the solution decreased to 6.8. This event caused a significant increase in the efficiency of cellular doxorubicin uptake and in vitro tumor inhibition.

show abstract

“…One major application of peptide‐based nanomaterials is for cancer therapy. The amphiphilic peptide (KLAKLAK) 2 (KLAK), a famous antitumor peptide through damaging the membrane of mitochondria, has been widely used for cancer therapy in vitro and in vivo . Recently, Wang and co‐workers developed a library of self‐assembled KLAK‐based nanomaterials from an in situ polymerization for cancer therapy ( Figure ) .…”

Section: Ex Situ Constructed Peptide‐based Nanomaterialsmentioning

confidence: 99%

Self‐Assembled Peptide‐Based Nanomaterials for Biomedical Imaging and Therapy

et al. 2018

View full text Add to dashboard Cite

Peptide-based materials are one of the most important biomaterials, with diverse structures and functionalities. Over the past few decades, a self-assembly strategy is introduced to construct peptide-based nanomaterials, which can form well-controlled superstructures with high stability and multivalent effect. More recently, peptide-based functional biomaterials are widely utilized in clinical applications. However, there is no comprehensive review article that summarizes this growing area, from fundamental research to clinic translation. In this review, the recent progress of peptide-based materials, from molecular building block peptides and self-assembly driving forces, to biomedical and clinical applications is systematically summarized. Ex situ and in situ constructed nanomaterials based on functional peptides are presented. The advantages of intelligent in situ construction of peptide-based nanomaterials in vivo are emphasized, including construction strategy, nanostructure modulation, and biomedical effects. This review highlights the importance of self-assembled peptide nanostructures for nanomedicine and can facilitate further knowledge and understanding of these nanosystems toward clinical translation.

show abstract

A novel pH-responsive polysaccharidic ionic complex for proapoptotic d-(KLAKLAK)2 peptide delivery

Cited by 42 publications

References 10 publications

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

The Use of Therapeutic Peptides to Target and to Kill Cancer Cells

A molecular zipping/unzipping nano-vehicles sensitive to tumor extracellular pH

Self‐Assembled Peptide‐Based Nanomaterials for Biomedical Imaging and Therapy

Contact Info

Product

Resources

About