The eradication rate of
Helicobacter pylori
(
H. pylori
) with proton pump inhibitors, amoxicillin, and clarithromycin has reportedly decreased. Some studies have found probiotics to be useful in eradicating
H. pylori
, but these effects have not been sufficiently investigated. We aimed to elucidate the role of probiotics in eradicating
H. pylori
infection. Patients in our hospital with
H. pylori
infection that received standard treatment from January 2015 to December 2016 were retrospectively evaluated (
n
= 468). They were divided into three groups based on their treatment regime, being either proton pump inhibitors, amoxicillin, or clarithromycin (PPI group), vonoprazan, amoxicillin, or clarithromycin (VPZ group), and proton pump inhibitors, amoxicillin, or clarithromycin/probiotics (Miya-BM
®
) (PPI + MBM group). We retrospectively evaluated the
H. pylori
eradication rate and reported side effects. According to intention-to-treat analyses, the eradication rate of
H. pylori
was significantly higher in the PPI + MBM group (87.1%) than in the PPI group (70.1%). There was no difference in side effects between any of the three groups. In conclusion, Miya-BM
®
may have an additive effect when included with eradication therapies for
H. pylori
.
Real-time TEER monitoring enabled us to evaluate the dynamic changes of intestinal epithelial barrier function. PHGG may have a protective effect against IFN-γ-induced barrier dysfunction by attenuating the paracellular hyperpermeability; thus, its promotion as a functional food is anticipated.
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