Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats

Suyama, Yosuke; Handa, Osamu; Naito, Yuji; Takayama, Shin; Mukai, Rieko; Ushiroda, Chihiro; Majima, Atsushi; Yasuda-Onozawa, Yuriko; Higashimura, Yasuki; Fukui, Akifumi; Dohi, Osamu; Okayama, Tetsuya; Yoshida, Naohisa; Katada, Kazuhiro; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Takagi, Tomohisa; Konishi, Hideyuki; Itoh, Yoshito

doi:10.1016/j.bbrc.2018.02.202

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…A number of researchers maintained that the penis vein injection for male rats is much easier, more quick, and simpler to accomplish than tail vein injection. 25,26 In Group 2, rats were orally administered 400 mg/…”

Section: In Vivo Pharmacokinetic Study In Ratsmentioning

confidence: 99%

Comparative Pharmacokinetic and Bioavailability Studies of Monotropein, Kaempferol-3-O-Glucoside, and Quercetin-4’-O-Glucoside After Oral and Intravenous Administration of Motiliperm in Rats

2020

JOMH

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Background and ObjectiveThis study has evaluated the pharmacokinetic parameters and bioavailabilities of monotropein, kaempferol-3-O-glucoside, and quercetin-4'-O-glucoside after administration of MOTILIPERM in rats. Material and MethodsFollowing the administration of MOTILIPERM, the plasma concentrations of each compound in rats were simultaneously determined by using liquid chromatography tandem mass spectrometry (LC-MS/MS).

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Section: In Vivo Pharmacokinetic Study In Ratsmentioning

confidence: 99%

Comparative Pharmacokinetic and Bioavailability Studies of Monotropein, Kaempferol-3-O-Glucoside, and Quercetin-4’-O-Glucoside After Oral and Intravenous Administration of Motiliperm in Rats

2020

JOMH

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“…NSAIDs constitute one of the most widely used classes of drugs, with more than 70 million prescriptions and more than 30 billion tablets sold annually in the United States [4]. Despite NSAIDs' beneficial effects, their use has been limited due to their side effects, such as mucosal injury to the gastrointestinal tract and the risk of thrombotic cardiovascular events [5,6]. To reduce the gastrointestinal side effects, NASIDs are frequently treated as a mixture form with proton pump inhibitors such as omeprazole, esomeprazole, and pantoprazole [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, for the enhancement of the drug potency, NSAIDs have been treated with caffeine as a fixed-dose combination [10,11]. Therefore, there are growing researches on the simultaneous analysis of the mixture forms regarding NSAIDs [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

High-Performance Liquid Chromatography for Determining a Mixture of Nonsteroidal Anti-inflammatory Drugs

Hassan

Nam

2021

Electron. Mater. Lett.

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Nonsteroidal anti-inflammatory drugs (NSAIDs), which block the activity of cyclooxygenase (COX) isoenzymes and inhibit the synthesis of prostaglandin, have been used for pain relief. For the enhancement of the potency or the decrease of sideeffects, NSAIDs are normally prescribed as a mixture with other chemical components including caffeine and proton pump inhibitor. Here, we developed a method to separate a mixture of three NSAIDs, such as aspirin, paracetamol, and naproxen, using reverse-phase high-performance liquid chromatography (RP-HPLC). An isocratic mobile phase consisting of acidic water and acetonitrile was selected to run at a low flow rate, such as 0.8 mL/min. The mixture of three NSAIDs was injected at a low volume into a C18 column having 150 mm in length and characterized using a UV detector at 230 nm. We identified three peaks in the chromatogram indicating three compounds. The elution time of the peaks was less than 10 min. The method proposed here can be used for identification of the combination of NSAIDs.

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are regarded as cyclooxygenase (COX) inhibitors and generally prescribed as pain relievers for headaches, rheumatoid arthritis, postoperative pain, and orthopedic fractures [18][19][20]. Despite NSAIDs' beneficial effects, their use has been limited due to their side effects, such as mucosal injury to the gastrointestinal tract and the risk of thrombotic cardiovascular events [21][22][23][24][25]. Aspirin (2acetoxybenzoic acid), paracetamol (N-acetyl-para-aminophenol), and naproxen [(S)-(+)-2-(6-Methoxy-2-naphthyl) propionic acid] are classic NSAIDs available in local drug stores.…”

Section: Introductionmentioning

confidence: 99%

Isocratic Reverse-Phase HPLC Method for Determination of Aspirin, Paracetamol, and Naproxen

Mm¹,

Nam²

2021

Preprint

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Nonsteroidal anti-inflammatory drugs (NSAIDs), which block the activity of cyclooxygenase (COX) isoenzymes and inhibit the synthesis of prostaglandin, have been used for pain relief. We have developed a method to separate a mixture of three NSAIDs, such as aspirin, paracetamol, and naproxen, using reverse-phase high-performance liquid chromatography (RP-HPLC). An isocratic mobile phase consisting of acidic water and acetonitrile was selected to run at a low flow rate, such as 0.8 mL/min. The mixture of three NSAIDs was injected at a low volume into a C18 column that was 150 mm in length and characterized using a UV detector at 230 nm. We identified three peaks in the chromatogram indicating the three compounds. The elution time of the peaks was less than 10 minutes. To identify multiple peaks on the isocratic flow using a short column, further studies are required regarding the proposed method to generate microfluidic devices for nanoLC.

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Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats

Cited by 13 publications

References 35 publications

Comparative Pharmacokinetic and Bioavailability Studies of Monotropein, Kaempferol-3-O-Glucoside, and Quercetin-4’-O-Glucoside After Oral and Intravenous Administration of Motiliperm in Rats

Comparative Pharmacokinetic and Bioavailability Studies of Monotropein, Kaempferol-3-O-Glucoside, and Quercetin-4’-O-Glucoside After Oral and Intravenous Administration of Motiliperm in Rats

High-Performance Liquid Chromatography for Determining a Mixture of Nonsteroidal Anti-inflammatory Drugs

Isocratic Reverse-Phase HPLC Method for Determination of Aspirin, Paracetamol, and Naproxen

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