Effectiveness of including probiotics to <i>Helicobacter pylori</i> eradication therapies

Abstract

The eradication rate of Helicobacter pylori ( H. pylori ) with proton pump inhibitors, amoxicillin, and clarithromycin has reportedly decreased. Some studies have found probiotics to be useful in eradicating H. pylori , but these effects have not been sufficiently investigated. We aimed to elucidate the role of probiotics in eradicating H. pylori infection. Patients in our hospital with H. pylori infection that received standard treatment from January 2015 to December 2016 were retrospectively evaluated ( n = 468). They were divided into three groups based on their treatment regime, being either proton pump inhibitors, amoxicillin, or clarithromycin (PPI group), vonoprazan, amoxicillin, or clarithromycin (VPZ group), and proton pump inhibitors, amoxicillin, or clarithromycin/probiotics (Miya-BM ® ) (PPI + MBM group). We retrospectively evaluated the H. pylori eradication rate and reported side effects. According to intention-to-treat analyses, the eradication rate of H. pylori was significantly higher in the PPI + MBM group (87.1%) than in the PPI group (70.1%). There was no difference in side effects between any of the three groups. In conclusion, Miya-BM ® may have an additive effect when included with eradication therapies for H. pylori .

Dietary intake of walnut prevented <i>Helicobacter pylori</i>-associated gastric cancer through rejuvenation of chronic atrophic gastritis

“…In clinic, the importance of either H. pylori eradication or their regulation impose significant impact on either gastric cancer prevention or gastric diseases amelioration, for which several kinds of intervention like natural products, probiotics, and more effective anti-H. pylori therapy are under active investigation. (68)(69)(70)(71) In conclusion, walnut seems to be very effective and attractive because of well-acknowledgement as "pharmanutrient" against H. pylori infection. However, welldesigned clinical trial should be followed.…”

Utilizing Probiotics for the Prevention and Treatment of Gastrointestinal Diseases

“…When combined with a triple therapy of omeprazol, clarithromycin, and amoxicillin, pre-treatment of patients with L. acidophilus, S. faecalis , and B. subtilis for two-weeks improved the eradication rate by 18.7% compared to the control ( Du et al, 2012 ). A 24-month clinical trial involving nearly 500 subjects found similar results with a combination of probiotic treatment and triple therapy increasing eradication rate by 7% ( Rieko et al, 2020 ). It is proposed that this colonization reduction may be due to a decrease in the biotic load despite H. pylori antimicrobial resistance ( Du et al, 2012 ).…”

Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

“…The incidence of peptic ulcers caused by H. pylori infection has markedly decreased in Japan because eradication therapy for H. pylori has been widely accepted. (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) Additionally, the infection rate of H. pylori has markedly decreased in Japan, (20,(31)(32)(33) especially in younger generations; the infection rate in junior high school students is <5%. (34) PPIs have recently become more frequently prescribed for secondary prevention of peptic ulcers and upper GI bleeding induced by NSAIDs and/or aspirin in Japan, (2,(35)(36)(37)(38) although the prescription of aspirin has increased in a time-dependent manner as demonstrated in Fig.…”