Northwest China includes Xinjiang Ugyur Autonomous Region, Qinghai Province, Gansu Province, Ningxia Hui Autonomous Region and Shaanxi Province, covering 308×10 4 km 2 . It is located in the warm-temperate zone and the climate is arid or semi-arid. Precipitation is very scarce but evaporation is extremely high. The climate is dry, the water resources are deficient, the eco-environment is fragile, and the distribution of water resources is uneven. In this region, precipitation is the only input, and evaporation is the only output in the inland rivers, and precipitation, surface water and groundwater change with each other for many times, which benefits the storage and utilization of water resources.The average precipitation in this region is 232 mm, the total precipitation amount is 7003×10 8 m 3 /a, the surface water resources are 1891×10 8 m 3 /a, the total natural groundwater resources are 1150×10 8 m 3 /a, the total available water resources are 438×10 8 m 3 /a, and the total water resources are 1996×10 8 m 3 /a and per capita water resources are 2278 m 3 /a. The water resources of the whole area are 5.94×10 4 m 3 /(a.km 2 ), being only one-fifth of the mean value in China. Now, the available water resources are 876×10 8 m 3 /a, among which groundwater is proximate 130×10 8 m 3 /a.
Methyladenosine modifications are the most abundant RNA modifications, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 2’-O-methyladenosine (m6Am). As reversible epigenetic modifications, methyladenosine modifications in eukaryotic RNAs are not invariable. Drastic alterations of m6A are found in a variety of diseases, including cancers. Dynamic changes of m6A modification induced by abnormal methyltransferase, demethylases, and readers can regulate cancer progression via interfering with the splicing, localization, translation, and stability of mRNAs. Meanwhile, m6A, m1A, and m6Am modifications also exert regulatory effects on noncoding RNAs in cancer progression. In this paper, we reviewed recent findings concerning the underlying biomechanism of methyladenosine modifications in oncogenesis and metastasis and discussed the therapeutic potential of methyladenosine modifications in cancer treatments.
DCE-MRI is an accurate technique for the assessment of spinal tumor vascularity, which may have a potential value in the decision-making of preoperative embolization.
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