Dynamic contrast-enhanced MRI for the assessment of spinal tumor vascularity: correlation with angiography

Meng, Xiaoxi; Zhang, Yongqiu; Liao, Huaqiang; Liu, Hong-chao; Jiang, Hailin; Ke, Shu-jun; Dong, Wei

doi:10.1007/s00586-016-4713-z

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…Because angiographic vascularity is not always consistent with histological tumor type, development of non-invasive methods to identify hypervascular tumors can reduce unnecessary costs and complications, and avoid the exclusion of unexpected hypervascular tumors. Meng et al (24), by analyzing its correlation with angiography, demonstrated that dynamic contrast-enhanced magnetic resonance imaging is an accurate technique for the assessment of spinal-tumor vascularity. They modified the criteria developed by Thiex et al (7) to determine tumor hypervascularity using magnetic resonance imaging.…”

Section: Discussionmentioning

confidence: 99%

“…Lesions were assigned a vascularity grade ( 1 – 3 ) according to tumor blush in the study by Meng et al. ( 24 ). Their criteria were as follows: grade 1 (hypovascular) for tumors with a vascularity or weak tumor blush equal to that of adjacent vertebral bodies without tumor involvement; grade 2 (moderate) for tumors with a moderate tumor blush greater than that of the adjacent vertebral bodies; and grade 3 (hypervascular) for tumors with a substantial tumor blush with arteriovenous shunting.…”

Section: Discussionmentioning

confidence: 99%

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Only Tumors Angiographically Identified as Hypervascular Exhibit Lower Intraoperative Blood Loss Upon Selective Preoperative Embolization of Spinal Metastases: Systematic Review and Meta-Analysis

et al. 2021

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BackgroundThe role of preoperative embolization (PE) in reducing intraoperative blood loss (IBL) during surgical treatment of spinal metastases remains controversial.MethodsA systematic search was conducted for retrospective studies and randomized controlled trials (RCTs) comparing the IBL between an embolization group (EG) and non-embolization group (NEG) for spinal metastases. IBL data of both groups were synthesized and analyzed for all tumor types, hypervascular tumor types, and non-hypervascular tumor types.ResultsIn total, 839 patients in 11 studies (one RCT and 10 retrospective studies) were included in the analysis. For all tumor types, the average IBL did not differ significantly between the EG and NEG in the RCT (P = 0.270), and there was no significant difference between the two groups in the retrospective studies (P = 0.05, standardized mean difference [SMD] = −0.51, 95% confidence interval [CI]: −1.03 to 0.00). For hypervascular tumors determined as such by consensus (n = 542), there was no significant difference between the two groups (P = 0.52, SMD = −0.25, 95% CI: −1.01 to 0.52). For those determined as such using angiographic evidence, the IBL was significantly lower in the EG than in the NEG group, in the RCT (P = 0.041) and in the retrospective studies (P = 0.004, SMD = −0.93, 95% CI: −1.55 to −.30). For IBL of non-hypervascular tumor types, both the retrospective study (P = 0.215) and RCT (P = 0.947) demonstrated no statistically significant differences in IBL between the groups.ConclusionsOnly tumors angiographically identified as hypervascular exhibited lower IBL upon PE in this study. Further exploration of non-invasive methods to identify the vascularity of tumors is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Only Tumors Angiographically Identified as Hypervascular Exhibit Lower Intraoperative Blood Loss Upon Selective Preoperative Embolization of Spinal Metastases: Systematic Review and Meta-Analysis

et al. 2021

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“…The spine has a complex anatomy, and its structures can overlap in radiography, leading to missed diagnoses when the lesion is located in the thoracic vertebrae or attachment areas of the spine. Under these conditions, MR, CT, and ECT can play important roles in the diagnosis of bone metastases 9,12,13 . Making timely and accurate diagnoses of bone metastases is critical for the treatment of cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…The MR technique provides good soft tissue resolution, is particularly sensitive to spinal tumors, 9 and can show minor abnormalities in bone marrow that display poorly on CT scans. However, for imaging calcification, ossification, fibrous tissue, and bone microstructure, MR is inferior to CT.…”

Section: Discussionmentioning

confidence: 99%

“…With the development of computer technology, traditional radiology has evolved into medical imaging, which utilizes X‐rays, computed tomographic scanning (CT), magnetic resonance (MR), ultrasound, and nuclear medicine techniques. These techniques have all been used to diagnose diseases of the skeletal system 7‐9 . Among them, CT and MR are the most commonly used for spinal disease 10 .…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of MR, CT, and ECT in the differentiation of neoplastic from nonneoplastic spine lesions

Liu

Liang

Bian

et al. 2020

Asia-Pac J Clncl Oncology

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Aim: To provide guidance for appropriate imaging examinations for diagnosing spinal tumors or tumor-like lesions. Methods: A total of 121 patients with suspected spinal tumors were included this retrospective study. Each patient underwent ≥2 imaging examinations, including computerized tomography (CT), magnetic resonance (MR), and/or emission computed tomography (ECT). All patients were diagnosed by pathology after core needle or surgical biopsies. The results were compared with those of pathological examinations using paired chi-squared tests, and compared with each other. Statistical indicators that tested the consistency of the results included McNemar's and kappa coefficients, as well as receiver operating characteristic curves. Results: The differences among MR, CT, ECT, and pathology were not significant. The kappa coefficient of MR, CT, and ECT was 46.1%, 36.0%, and 55.9%, respectively. The area under the curve of ECT, MR, and CT scans was 0.809, 0.705, and 0.704, respectively; and the differences among them were significant (P < .05). Post hoc multiple comparisons showed no significant differences among imaging examinations in terms of sensitivity, specificity, misdiagnosis rate, and coincidence rate (P > .05). However, significant differences were noted in the kappa coefficient and missed diagnosis rate (P < .05). Conclusions: Although ECT was the most accurate imaging method, its high cost and large radiation dosage limit its widespread application. Furthermore, MR verified spinal tumors more effectively; however, CT excluded them more efficiently. In summary, when all factors are considered, MR is still the optimal modality for the diagnosis of spinal tumors, especially during the initial screening.

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Local and Distant Staging

Labbène

Ladeb

2023

Imaging of Primary Tumors of the Osseous Spine

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Dynamic contrast-enhanced MRI for the assessment of spinal tumor vascularity: correlation with angiography

Abstract: DCE-MRI is an accurate technique for the assessment of spinal tumor vascularity, which may have a potential value in the decision-making of preoperative embolization.

Cited by 9 publications

References 21 publications

Only Tumors Angiographically Identified as Hypervascular Exhibit Lower Intraoperative Blood Loss Upon Selective Preoperative Embolization of Spinal Metastases: Systematic Review and Meta-Analysis

Only Tumors Angiographically Identified as Hypervascular Exhibit Lower Intraoperative Blood Loss Upon Selective Preoperative Embolization of Spinal Metastases: Systematic Review and Meta-Analysis

Diagnostic accuracy of MR, CT, and ECT in the differentiation of neoplastic from nonneoplastic spine lesions

Local and Distant Staging

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