Cohesive subgraph mining in bipartite graphs becomes a popular research topic recently. An important structure k-bitruss is the maximal cohesive subgraph where each edge is contained in at least k butterflies (i.e., (2, 2)-bicliques). In this paper, we study the bitruss decomposition problem which aims to find all the k-bitrusses for k ≥ 0. The existing bottomup techniques need to iteratively peel the edges with the lowest butterfly support. In this peeling process, these techniques are time-consuming to enumerate all the supporting butterflies for each edge. To relax this issue, we first propose a novel online index -the BE-Index which compresses butterflies into k-blooms (i.e., (2, k)-bicliques). Based on the BE-Index, the new bitruss decomposition algorithm BiT-BU is proposed, along with two batchbased optimizations, to accomplish the butterfly enumeration of the peeling process in an efficient way. Furthermore, the BiT-PC algorithm is devised which is more efficient against handling the edges with high butterfly supports. We theoretically show that our new algorithms significantly reduce the time complexities of the existing algorithms. Also, we conduct extensive experiments on real datasets and the results demonstrate that our new techniques can speed up the state-of-the-art techniques by up to two orders of magnitude.

Numerical simulations of the elastohydrodynamic lubrication (EHL) have been conducted by many researchers, in which the entrainment velocity is usually parallel to one of the axes of Hertzian contact ellipse. However, in some engineering applications, such as the counterformal contacts in spiral bevel and hypoid gears, entraining velocity vector may have an oblique angle that could possibly influence the lubrication characteristics significantly. Also, a vast majority of gears operate in mixed EHL mode in which the rough surface asperity contacts and lubricant films coexist. These gears are key elements widely used for transmitting significant power in various types of vehicles and engineering machinery. Therefore, model development for the mixed EHL in elliptical contacts with an arbitrary entrainment angle is of great importance. In the present paper, a recently developed mixed EHL model is modified to consider the effect of arbitrary entraining velocity angle, and the model is validated by comparing its results with available experimental data and previous numerical analyses found in literature. Based on this, numerical simulations are conducted to systematically study the influence of entrainment angle on lubricant film thickness in wide ranges of speed, load, and contact ellipticity. The obtained results cover the entire lubrication spectrum from thick-film and thin-film lubrication all the way down to mixed and boundary lubrication. In addition, minimum film thickness prediction formula is also developed through curve-fitting of the numerical results.

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The thermo-sensitive hydrogels with high drug loading rate achieved sustained drug release over 2 weeks. Histopathological examination of retina confirmed the excellent biocompatibility and effective anti-inflammatory property of the hydrogel.

A new neurotoxin BmK M2, toxic to both mammals and insects, with the strongest toxicity in the BmK toxin series, has been purified from the Chinese scorpion Buthus martensii Karsch and crystallized with MPD at pH 7.5. The crystals are orthorhombic, belonging to space group P2(1)2(1)2(1), with unit-cell parameters a = 36.64, b = 36.95, c = 37.23 A. The structure was solved by molecular replacement and refined to R = 0.186 for all reflections to a resolution of 1.76 A. The whole sequence (64 residues) of BmK M2 was determined by crystallographic analysis based on high-resolution data and the homologous model of BmK M8. The refined BmK M2 structure shows a non-proline cis peptide bond between Pro9 and His10 which enables the C-terminal segment to adopt a conformation different to that of the weak toxin BmK M8. Recently, a mutation analysis had suggested that both the tenth residue and the C-terminus play key roles in receptor binding. Therefore, these features may be related to the binding selectivity of the group III alpha-like toxins. The charge changes of residues 8, 10, 18, 28, 55 and 59 from neutral or negative to positive or neutral, which leads to a positive electrostatic potential surface, may be responsible for the high toxicity of BmK M2.

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The tertiary amino effect reaction was explored and developed for application to DNA-encoded library synthesis.

SA-NPs were constructed to target the treatment of AKI and improve therapeutic efficiency and reduce side effects.