The thermo-sensitive hydrogels with high drug loading rate achieved sustained drug release over 2 weeks. Histopathological examination of retina confirmed the excellent biocompatibility and effective anti-inflammatory property of the hydrogel.
Background:
Indomethacin (IND) is a class of non-steroidal anti-inflammatory drugs that is used to treat various kinds of ocular inflammation, and has been reported that could prevent posterior capsule opacification (PCO) by inhibiting the mitosis and collagen synthesis of human lens epithelial cells (LECs). In addition, the specific absorption spectrum of indomethacin has the effect of absorbing short-wavelength blue-violet light.
Objective:
We intend to prepare a hydrogel loaded with indomethacin as potential intraocular lens (IOLs) material that can prevent endophthalmitis, PCO and filter harmful blue light.
Method:
Indomethacin prodrug (HEMA-IND) (HI) were prepared by esterification of indomethacin and 2-hydroxyethyl methacrylate (HEMA), and poly (HEMA-co-MAA-co-MMA-co-HI) (HAMI) hydrogels were prepared by free radical polymerization of 2-hydroxyethyl methacrylate (HEMA), methyl methacrylate (MMA), methacrylic acid (MAA) and HI. And their physical and chemical properties, drug release behavior and cytotoxicity were determined.
Results:
HAMI hydrogels can filter harmful short-wavelength blue light and showed other necessary properties like visible light transparency, glass transition temperatures, mechanical strength, and biocompatibility for making intraocular lenses. In addition, MAA increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and faster drug release from the hydrogels.
Conclusion:
In summary, HAMI hydrogels show great potential as IOL biomaterials that can maintain the sustained release of indomethacin and filter harmful blue light after cataract surgery.
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