A thermo-sensitive, injectable and biodegradable <i>in situ</i> hydrogel as a potential formulation for uveitis treatment

Zou, Mengwei; Jin, Rongrong; Hu, Yanfei; Zhang, Ying; Wang, Haibo; Liu, Gongyan; Nie, Yu; Wang, Yunbing

doi:10.1039/c9tb00939f

Cited by 19 publications

(12 citation statements)

References 72 publications

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“…For instance, Awwad and coworkers developed injectable hydrogels derived from NIPAM and hyaluronic acid (HA) to obtain extended release of proteins . A similar study was conducted by Zou et al . In this study, an in situ injectable thermoresponsive hydrogel composed of NIPAM was fabricated to have drug‐conjugated polymer.…”

Section: Introductionmentioning

confidence: 84%

Thermoresponsive hydrogels based on renewable resources

Koca

Bozdağ

Çaylı

et al. 2019

J of Applied Polymer Sci

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This work aims to synthesize novel thermoresponsive hydrogels from renewable resources, bacterial cellulose (BC), and castor oil (CO), and to investigate the effect of CO on physical and thermal behaviors of BC/Poly(N‐isopropylacrylamide) (PNIPAM) hydrogels. The structural properties of the hydrogels are analyzed by Fourier‐transform infrared (FTIR) spectroscopy. Differential scanning calorimeter (DSC) technique and thermogravimetric analysis (TGA) are also performed to examine the thermal properties of the hydrogels. The morphological differences of the hydrogels are analyzed by scanning electron microscope (SEM). The thermoresponsive performances of the hydrogels are examined by swelling and deswelling behaviors. The hydrogel with CO is found to be more sensitive to temperature changes than the one without CO. Deswelling study demonstrates 91 and 25% of water loss for hydrogels with and without CO, respectively. The present study shows a novel approach to synthesize thermoresponsive hydrogels with renewable resources for biomedical applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48861.

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Section: Introductionmentioning

confidence: 84%

Thermoresponsive hydrogels based on renewable resources

Koca

Bozdağ

Çaylı

et al. 2019

J of Applied Polymer Sci

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“…As its cloud point (CP) is around 31°C, and independent of the MM and composition, 206 it has attracted much interest for biomedical applications. Due to its promising properties, in vivo applications of NIPAAm-based random, [139][140][141][142]144 block, [146][147][148] branch, 149-153 conjugate 163,164 and star 166 synthetic copolymers as well as NIPAAm-based polymers covalently 20,143,[154][155][156][157][158][159][160][161] or physically mixed 143,145,151,152 with natural components were reported in the literature.…”

Section: Pnipaam-based Trgsmentioning

confidence: 99%

“…Random NIPAAm-based copolymers, synthesised via freeradical polymerisation, were applied in model animals as TRGs. [139][140][141][142]144 Several units have been used as comonomers such as acrylic acid (AA), 141,142 γ-butyrolactone acrylate, 142 Nhydroxysuccinimide, 141 acryloyloxy dimethyl-γ-butyrolactone, 141 poly(ethylene glycol) methyl ether methacrylate, 140 methacrylic acid 140,144 and n-butyl acrylate (BuA). 139 Upon injection of the solutions in model animals, in situ gelation [139][140][141][142] and in vivo biocompatibility were confirmed.…”

Section: Pnipaam-based Trgsmentioning

confidence: 99%

“…140 In another study, a macromonomer on which the drug was covalently linked, namely 2-hydroxyethylmethacrylate-g-poly(trimethylene carbonate)indomethacine, was copolymerised with NIPAAm, and antiinflammatory action for treatment of uveitis was confirmed. 144 In an interesting study by Bayat et al, the TRG was in vivo investigated as a possible sealant in ocular trauma. 139 The solution was injected using an in-house developed syringe, and practical workshops in which this copolymer solution was applied ex vivo in pig eyes were held.…”

Section: Pnipaam-based Trgsmentioning

confidence: 99%

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Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Constantinou

Georgiou

2021

Polymer International

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Thermoreversible polymer hydrogels (TRGs) are physical aqueous networks triggered by temperature that find potential applications in tissue engineering (TE) and drug/gene delivery. When systems with lower critical solution temperature (LCST) behaviour are used, the aqueous solution of polymer is mixed with cells or drugs/genes, depending on the desired application, at room temperature and then injected in vivo to form a hydrogel. This in situ forming hydrogel acts as a matrix for tissue regeneration or controlled and targeted release of the compound. This review focuses on discussing the studies in which synthetic TRGs with LCST behaviour have been applied in vivo in model animals. These studies are categorised depending on the general structure of the polymer, as follows: (i) poloxamers (also known as Pluronics®), (ii) degradable polymers, (iii) poly(N-isopropylacrylamide), (iv) poly(organophosphazene) and (v) poly(2-ethyl-2-oxazoline). In general, when the system is optimised, TRGs provide sustained and topical release of the drugs, thus minimising the undesired side effects. When applied in the TE field, tissue formation was observed. Interestingly, two polymers have reached clinical trials, namely poloxamer 407 (P407, Pluronic® F127, often combined with P188, F68) and Regel® (the formulation of Regel® with the anticancer agent paclitaxel is known as Oncogel®), indicating the challenges that need to be overcome before successful application in clinics.

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“…It may also affect retina, vitreous, sclera, and optic nerve. It is associated with about 10% of the blindness cases in the whole world [ 1 ]. Uveitis may be classified anatomically into anterior uveitis which includes anterior chamber, intermediate uveitis involves vitreous body, posterior uveitis which affects choroid and retina, and panuveitis which affects all layers of the uvea.…”

Section: Introductionmentioning

confidence: 99%

Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation

2021

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Treatment of uveitis (i.e., inflammation of the uvea) is challenging due to lack of convenient ophthalmic dosage forms. This work is aimed to determine the efficiency of triamcinolone acetonide (TA)-loaded microemulsion as an ophthalmic delivery system for the treatment of uveitis. Water titration method was used to construct different pseudo-ternary phase diagrams. Twelve microemulsion formulations were prepared using oleic acid, Cremophor EL, and propylene glycol. Among all tested formulations, Formulation F3, composed of oil: surfactant-co-surfactant (1:1): water (15:35:50% w/w, respectively), was found to be stable and showed acceptable pH, viscosity, conductivity, droplet size (211 ± 1.4 nm), and zeta potential (−25 ± 1.7 mV) and almost complete in vitro drug release within 24 h. The in vivo performance of the optimized formulation was evaluated in experimentally uveitis-induced rabbit model and compared with a commercial TA suspension (i.e., Kenacort®-A) either topically or by subconjunctival injection. Ocular inflammation was evaluated by clinical examination, white blood cell count, protein content measurement, and histopathological examination. The developed TA-loaded microemulsion showed superior therapeutic efficiency in the treatment of uveitis with high patient compliance compared to commercial suspension. Hence, it could be considered as a potential ocular treatment option in controlling of uveitis.

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A thermo-sensitive, injectable and biodegradable in situ hydrogel as a potential formulation for uveitis treatment

Abstract: The thermo-sensitive hydrogels with high drug loading rate achieved sustained drug release over 2 weeks. Histopathological examination of retina confirmed the excellent biocompatibility and effective anti-inflammatory property of the hydrogel.

Cited by 19 publications

References 72 publications

Thermoresponsive hydrogels based on renewable resources

Thermoresponsive hydrogels based on renewable resources

Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review

Development of Triamcinolone Acetonide-Loaded Microemulsion as a Prospective Ophthalmic Delivery System for Treatment of Uveitis: In Vitro and In Vivo Evaluation

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