Development of inclusion complex of brinzolamide with hydroxypropyl-β-cyclodextrin

Zhang, Ying; Ren, Ke; He, Zhiyao; Li, Huili; Chen, Tong; Lei, Yi; Shan, Xia; He, Gu; Xie, Yongmei; Zheng, Yu; Song, Xiangrong

doi:10.1016/j.carbpol.2013.06.052

Cited by 35 publications

(12 citation statements)

References 13 publications

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“…These in vitro results inspired us to perform in vivo experiments aimed at testing the anti-inflammatory effects of drug-loaded, sustained-release IOLs based on the pHEMA/MMA/β-CD hydrogels presented in this study, and these results will be reported in a later publication. In addition, previous studies demonstrated that β-CD can encapsulate a variety of small molecule drugs, including antibiotics and anti-glaucoma drugs [ 56 , 57 ]. Therefore, IOLs composed of pHEMA/MMA/β-CD hydrogels may be useful for treating complicated cataracts, including uveitis cataract and glaucoma with cataract.…”

Section: Discussionmentioning

confidence: 99%

Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release

Zhao

Wang

et al. 2017

PLoS ONE

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To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization. The polymers had high transmittance at visible wavelengths and good biocompatibility with mouse connective tissue fibroblasts. Drug loading and release studies demonstrated that introducing β-CD into hydrogels increased loading efficiency and achieved the sustained release of the drug. Administering β-CD via hydrogels increased the equilibrium swelling ratio, elastic modulus and tensile strength. In addition, β-CD increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and higher cellular adhesion to the hydrogels. In summary, pHEMA/MMA/β-CD hydrogels show great potential as IOL biomaterials that are capable of maintaining the sustained release of anti-inflammatory drugs after cataract surgery.

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Section: Discussionmentioning

confidence: 99%

Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release

Zhao

Wang

et al. 2017

PLoS ONE

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“…The initial weight loss observed until about 100 o C is due to the water loss in the structure (Zhang et al, 2013b;Trotta, Zanetti, Camino, 2000). In the physical mixture (yellow line), two baseline temperatures were observed, one can be associated with TMZ (227 o C) and the other with β-CD (351 o C).…”

Section: Complex Formationmentioning

confidence: 97%

“…Generally, drugs should be sufficiently hydrophobic in order to penetrate biological membranes via passive diffusion, but at the same time possess some hydrophilicity in aqueous medium. For many pharmaceutical applications, it was shown that inclusion complex helped to improve solubility (Aiassa et al, 2015; Atipairin, Sawatdee, 2016; Freitas et al, 2012;Ol'khovich et al, 2014;Priya et al, 2013;Shende et al, 2015;Zhang et al, 2013a;Zhang et al, 2013b;Franco et al, 2009;Ruan et al, 2005;Tang et al, 2015;De Araujo et al, 2008), stability (Freitas et al, 2012;Shende et al, 2015;Kicuntod et al, 2016), bioavailability (Atipairin, Sawatdee, 2016;Zhang et al, 2013a), and therapeutic effect (Zhang et al, 2013b), between various drugs and cyclodextrins. Inclusion complexes of epothilone (Xiao et al, 2014), oxaliplatin (Zhang et al, 2016), paclitaxel (Hamada et al, 2006), etc.…”

Section: Introductionmentioning

confidence: 99%

Complexation and enhancement of temozolomide solubility with cyclodextrins

Gurten

Yenigül

Sezer

et al. 2018

Braz. J. Pharm. Sci.

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Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhance its solubility. In this study, three different cyclodextrins (β-CD, hydroxyl-β-CD and γ-CD) were used, and changes in solubility was measured by UV-Vis Spectroscopy and HPLC. Morphological changes upon complexation were shown by the Scanning Electron Microscope (SEM), and weight loss profiles with respect to temperatures which were unique to the compounds were shown by Thermogravimetric Analysis. Changes in heat release profiles were shown by Differential Scanning Calorimeter (DSC). Drug solubility was measured to be increased to around 25% for 1:1 molar ratio for all used CD complexations. Changes of morphology, heat release and weight loss profiles are consistent with the formation of an inclusion complex between CDs and temozolomide. In this study, success was shown in the enhancement of temozolomide solubility upon complexation with different types of CDs. It has been demonstrated that cyclodextrins can be used as complexing agents for poorly soluble anti-cancer drugs, increasing their solubility and hence drug availability.

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“…They are able to form inclusion complexes with a wide variety of guest molecules [14][15]. The guest molecule has been the most favorable changes in the physicochemical properties, like stability, dissolution rate, solubility, and bioavailability due to inclusion complex formation between the drug molecules with CDs [16][17][18]. The cyclodextrins are used in food [19], pharmaceuticals [20], cosmetics [21], environment protection [22], bioconversion [23][24], packing and the textile industry [25], drug delivery [26], nano-structures [27], supramolecular polymers [28], selfhealing materials [29], amphiphiles [30], bioactive materials [31] or in the solubilization of hydrophobic monomers or RAFT agents [32][33].…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Preparation, characterization and molecular modeling studies of the inclusion complex of Caffeine with Beta-cyclodextrin

Prabu

Swaminathan

Sivakumar

et al. 2015

Journal of Molecular Structure

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Development of inclusion complex of brinzolamide with hydroxypropyl-β-cyclodextrin

Cited by 35 publications

References 13 publications

Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release

Cyclodextrin-containing hydrogels as an intraocular lens for sustained drug release

Complexation and enhancement of temozolomide solubility with cyclodextrins

Preparation, characterization and molecular modeling studies of the inclusion complex of Caffeine with Beta-cyclodextrin

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