During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negative clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant
Epstein-Barr virus (EBV) is detected in several human cancers, such as Burkitt’s lymphoma (BL), nasopharyngeal carcinoma, gastric cancer, and peripheral T-cell lymphoma. However, the role of EBV in the development of these cancers is still controversial. During cultivation of the EBV-positive BL line Akata, we found that EBV DNA is lost from some of the cells. Isolation of EBV-positive and -negative cell clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant phenotypes of BL, such as the growth in low serum, anchorage-independent growth, and tumorigenicity in nude mice, are dependent on the presence of EBV genomes and underline the oncogenic function of EBV in human cancer.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.