During cultivation of the Epstein-Barr virus (EBV)-positive Burkitt's lymphoma (BL) line Akata, it was noted that EBV DNA is lost from some of the cells. Isolation of EBV-positive and EBV-negative clones with the same origin made it possible to examine the effects of EBV in BL cells. The results indicate that malignant
Novel antiviral antibiotic quartromicins A1 and 01, isolated from Amyco/atopsis orienta/is, significantly inhibited human immunodeficiency virus (HIV)-induced cytopathic effect and virus specific antigen expression at concentrations of 25-100/1g rnl"" in MT-4 cells infected with HTLV-III B • The reverse transcriptase activity of disrupted HTLV-III B particles, recombinant HIV-1 enzyme, and purified avian myeloblastosis virus (AMY) enzyme were also significantly inhibited by quartromicins A1 and 01. The combined antiviral effect of quartromicin A1 and AZT on the replication of HIV in MT-4 cells was also examined. Quartromicin A1 synergistically enhanced the inhibitory effect of AZT as revealed by HIV-specific antigen expression.
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