Anti-human Immunodeficiency Virus (HIV) agents are also potent and selective inhibitors of Feline Immunodeficiency Virus (FIV)-induced cytopathic effect: Development of a new method for screening of anti-FIV substances in vitro

Factors That Increase the Effective Concentration of CXCR4 Dictate Feline Immunodeficiency Virus Tropism and Kinetics of Replication

“…HSPGs are well known in virus research since they have often been implicated as adsorption receptors for many viruses, including HIV and FIV (4,9,35,40). Here we showed that HSPGs can facilitate FIV infection, at least with laboratory-adapted strains such as FIV-34TF10, a virus that has been adapted to grow on CrFK cells (39).…”

Binding of Recombinant Feline Immunodeficiency Virus Surface Glycoprotein to Feline Cells: Role of CXCR4, Cell-Surface Heparans, and an Unidentified Non-CXCR4 Receptor

“…These studies have also shown that soluble heparans such as heparin or dextran sulfate inhibited replication of X4 HIV strains by specific binding to the V3 loop of gp120. A similar inhibition mediated by heparin and dextran sulfate was also reported for FIV (77). To elucidate whether HSPGs could also be involved in 34TF10 gp95-Fc binding, we first performed a competition study with heparin.…”

Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma

“…This small-animal model is a useful and costeffective system for the study of lentivirus immunopathogenesis and antiviral interventions (4). FIV is susceptible to nucleoside analogues, such as ZDV, zalcitabine, didanosine, and lamivudine (3TC; ␤-D-2Ј,3Ј-dideoxy-3Ј-thiacytidine), in vitro at concentrations similar to those observed with HIV-1 (22,23,29,31). The sensitivities of FIV and HIV-1 to the active triphosphate forms of ZDV and 3TC are also similar (21,27).…”