The intra- and inter-day accuracy and precision values for AMD and ATL met the acceptance as per regulatory guidelines. The validated assay was applied to a fixed-dose combination of AMD and ATL (Adopin-AT(®)) PK study in humans.
Hydrazinyl purine derivatives react with acetonyl acetone in presence of glacial acetic acid in alcohol form respective pyrrole derivatives. Hydrazinyl purine derivatives react with acetyl acetone in presence of catalytic amount of hydro chloric acid in water form respective pyrazole derivatives. The structures of these compounds have been established by 1 H NMR studies, IR studies and Mass data. This docking study explores the anti-mitotic activities of pyrrole and pyrazole derivatives of purine. The result from the docking study showed that pyrazole derivatives had excellent anti-mitotic activity that was comparable to the activity of abacavir.
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