Hydrazinyl purine derivatives react with acetonyl acetone in presence of glacial acetic acid in alcohol form respective pyrrole derivatives. Hydrazinyl purine derivatives react with acetyl acetone in presence of catalytic amount of hydro chloric acid in water form respective pyrazole derivatives. The structures of these compounds have been established by 1 H NMR studies, IR studies and Mass data. This docking study explores the anti-mitotic activities of pyrrole and pyrazole derivatives of purine. The result from the docking study showed that pyrazole derivatives had excellent anti-mitotic activity that was comparable to the activity of abacavir.
The Reaction of 4, 6-dichloropyrimidine-2, 5-diamine hydro chloride with different substituted anilines in presence of alcohol results in the formation of aryl substituted pyrimidine derivatives (1-5). Aryl substituted pyrimidine derivatives react with Tri ethyl ortho formate in presence of acid form respective 6-chloro purine derivatives (6-10). Further 6-chloro purine derivatives react with cyclopropyl amine results in the formation of substituted purinyl derivatives (11-15). The structures of these compounds have been established by 1 H NMR studies, IR studies and Mass data. All the substituted purinyl derivatives were screened for their antimicrobial activity against four bacteria and three fungi activities. Some of the compounds found to have fairly good activity.
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