Synthesis, characterization and pharmacological studies of sulphur containing 1,2,4-triazole derivatives

Magnetically Recoverable Cu0/Fe3O4‐Catalysed One‐Pot Tandem Synthesis of Sulfur‐Containing Triazoles from Alkynes and Azide: DMSO Acts as an Alkylating Agent

“…Based on our findings and on literature reports,[7c], a plausible mechanism for the synthesis of sulfur‐containing triazoles from alkynes and TMSN 3 is shown in Scheme . Initially, the oxygen of the polarised DMSO attacks TMSN 3 , leading to the formation of intermediate A along with release of azide ion.…”

“…In the recent past, sulfur‐containing triazoles in particular have also gained huge momentum, due to their presence in a wide variety of therapeutically interesting drug candidates, such as mPGES‐1 and antiinflammatory agents . Despite their being an integral part of life‐saving drugs, surprisingly, the synthesis of sulfur‐containing triazoles remains rather underexplored . The methods available in the literature have various disadvantages, such as harsh reaction conditions, expensive starting materials, long reaction times, and laborious and complex work‐up procedures.…”