Biological evaluation and spectral characterization of 4-hydroxy coumarin analogues

In silico Investigation and Biological Evaluation of Synthesized Sulfamethoxazole Derivatives

“…A series of phenolic/enolic substituted azosulfamethoxazoles 4a-4f were synthesized by the in situ reactions between diazotised SMZ and 6 different individual phenolic and enolic compound under mild conditions. All the proposed isoxazole derivatives were synthesized, physical properties and spectral interpretation were made (Table 1), which were similar to those reported earlier [8][9][10][11][12] .…”

“…The synthetic procedures of compounds (4a-4f) have been previously reported ( fig. 1) [8][9][10][11][12] . A cold solution of sodium nitrite was added dropwise to an aqueous solution of the desired SMZ with concentrated hydrochloric acid; the temperature of the reaction mixture was maintained at 0-5°.…”

“…Previous studies from our laboratory explored the synthesis and characterisation of phenolic/enolic substituted diazenyl SMZ derivatives [8][9][10][11][12][13][14] . To continue these efforts, biological activities of these analogues needs to be evaluated using different models.…”

In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline

“…The antimicrobial activity of the novel metal complexes of 8-hydroxyquinolineazo analogues were performed by agar well diffusion method using sterile molten nutrient agar and Sabouraud dextrose agar medium respectively for antibacterial and antifungal investigation. 28 The diameter of zone of inhibition was measured using the Hi-Antibiotic Zone Scale (Hi-Media). Each test compound was screened six times against individual strains.…”

Design, Synthesis and Pharmacological Evaluation of 4‐Hydroxycoumarin Derivatives as Antiproliferative Agents.

“…These compounds can inhibit the non‐structural 5B protein (NS5B), a protein that is important for the replication of Hepatitis C Virus (HCV) . Besides, coumarin derivatives are also known to have other pharmacological applications such as antimicrobial activity„ anti‐tubercular activity, antileishmanial activity, antioxidant activity and antidiabetic activity…”