Resumo -O propósito deste foi sintetizar os principais resultados de estudos que analisaram a relação do polimorfismo de nucleotídeo simples (SNP) rs9939609 do gene FTO (fat mass and obesity associated), com a manifestação de sobrepeso / obesidade e suas co-morbidades e discutir a interação deste polimorfismo com os demais fatores promotores da obesidade. A busca foi realizada nas bases de dados MEDLINE, Highwire, Science Direct e SciELO, usando as palavras-chave: FTO rs9939609, obesity genetic, gene associated obesity, FTO contributes obesity. Os critérios de inclusão foram: artigos originais que envolveram seres humanos e que incluíram o rs9939609. Foram excluídos os artigos que analisaram o gene FTO em grupos com doenças hormonais pré-instaladas. Dos vários SNPs contidos no gene FTO, o rs9939609 tem sido o mais pesquisado. Este SNP é composto pelos alelos A e T, sendo os homozigotos A os mais susceptíveis ao desenvolvimento de sobrepeso / obesidade em todas as idades, principalmente, em populações caucasianas. Nessa situação, o controle dos fatores ambientais (alimentação e atividade física) pode prevenir o acúmulo excessivo de gordura. A obesidade está relacionada ao desenvolvimento de doenças crônicas não-transmissíveis. Foram observadas associações do rs9939609 com o perfil lipídico sanguíneo e a glicemia. A prática de exercícios físicos e a alimentação parecem ser os principais influenciadores no desenvolvimento do sobrepeso / obesidade e na instalação das co-morbidades associadas. Palavras-chave: Obesidade; Sobrepeso; Estilo de vida; Co-morbidade; Genética. Abstract -The purpose of this work was to review the main results of studies that have analysed the relationship between the rs9939609 single nucleotide polymorphism (SNP) of the FTO gene and the manifestation of overweight/obesity with its associated co-morbidity, and to discuss the interaction of this polymorphism with the other factors which

Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. RESUMOObjetivo: verificar a resposta da pressão arterial (no decorrer de 24h) após uma sessão de HIIT com o protocolo Tabata, bem como o comportamento da frequência cardíaca nesse período. Método: foram avaliados 17 indivíduos de ambos os sexos (seis homens e 11 mulheres) com idades entre 16 e 37 anos, que realizaram o protocolo de HIIT Tabata em cicloergômetro, sendo mensurada a pressão arterial e a frequência cardíaca dos mesmos, em repouso, após o aquecimento, logo após a realização do protocolo, após cinco, dez, 20, 30, 40, 50 e 60 minutos e 24 horas. Os dados obtidos foram comparados através da ANOVA para medidas repetidas, e para determinar e avaliar as diferenças foi utilizado o post hoc de Bonferroni, adotando uma significância de p ≤0,05. Resultados: foi identificado que há uma resposta hipotensora da pressão arterial sistólica a partir de 40 minutos, porém sem diferenças em 24 horas, sem diferenças significantes para diastólica, com o comportamento da frequência cardíaca dentro do esperado no período pós-HIIT. Considerações finais: no presente estudo, o HIIT gerou resposta hipotensora a partir de 40 minutos, após o término de sua execução e essa se mantem constante até o período de 60 minutos na pressão arterial sistólica. Este comportamento não foi encontrado na pressão arterial diastólica e, a frequência cardíaca, apresentou o comportamento de acordo com o esperado para outros protocolos de esforço físico moderado a intenso. INTRODUÇÃOPressão sanguínea corresponde à força que o sangue exerce contra qualquer parede de vasos, gerando uma pressão ou tensão nos mesmos.1 A Pressão Arterial possui um comportamento inconstante, durante o dia e varia de acordo a necessidade de maior ou menor tensão nos vasos, que relacionado ao comportamento físico, como parado, andando, correndo e emocional.

Background Aging is an irreversible process by which all living humans will pass, and the percentage of older population growth significantly in the last decades. There are an increasing evidence showing that independently older people, with autonomy and physical capacity, has better quality of life in comparison with others without self-sufficiency. Objective: Verify the changes on Quality-of-Life (QoL), body composition and physical performance (PF) of elderly women submitted to resistance training (RT). Methods: 16 elderly women participated in the study, that consisted in 12 weeks of Resistance training. The QoL with SF-36, the blood pressure (BP), hand-grip strength, anthropometry and physical performance to senior, was measured before and after of resistance training. Results: The main findings of this study were that the RT for 12 weeks are able to changes the self-perception of QoL of elderly women, simultaneously with decrease in percent of fat and increase in strength and PF. In addition, a maintenance of BP levels, flexibility and self-perception of pain and global health (QoL domains), were observed after this period. Conclusion: The study suggest that the 12 weeks of RT, twice a week, is able to ameliorate several physical fitness components and QoL domains, in community-dwelling elderly women.

Background: Patients undergone hemodialysis (HD) suffer with energy-protein malnutrition, uremic myopathy and protein catabolism reducing their functional capacity, tolerance to exercise and aspects related to quality of life. Objective: The aim of this study was to evaluate the effects of the two protocols of inspiratory muscle training (IMT) on muscle strength, pulmonary function and related-health quality of life on male HD patients. Methods: Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), peak expiratory flow (PEF), forced expiratory volume in first second (FEV 1 ), forced vital capacity (FVC) and the FEV 1 /FVC ratio and quality of life were evaluated pre and post six months of IMT in HD patients. IMT was performed by one group using a specific training (Power breathe) device (T-IMT, n=19) and by the other with incentive spirometry (I-IMT, n= 15). Results: Following the inspiratory training, muscle strength improved in both groups. The group that used incentive spirometry had increments in MIP larger (39.8%, p<0.001) than the group that trained with the specific training device (28.3%, p=0.001). The KDQOL-SF dimensions showed significant difference in the T-IMT group in cognitive function (p=0.03), sexual function (p=0.009) and social function dimensions (p=0.04) and in the I-IMT group in the physical function dimension (p=0.03). Conclusion: It was proved that IMT improved muscle strength and I-IMT promoted increments significantly larger in MIP. Aspects of health-related quality of life of HD male patients improved significantly with T-IMT (sexual, social and cognitive functions), while I-IMT ameliorated only physical function.

Purpose. To determine whether risk factors for cardiovascular diseases (anthropometry, blood pressure, blood lipid profile) differ between men classified into the three relative body fat %BF categories (%BF £ 19: healthy; %BF > 19 and %BF < 30: overweight, and %BF ³ 30: obesity). Basic procedures. A total of 112 volunteers from Brasília, Brazil, were submitted to the measurement of body weight, height and waist, abdominal and hip circumference. The body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. %BF and body fat topography (arm, leg and trunk %BF) were estimated by dual-energy X-ray absorptiometry (DXA). Blood pressure was measured by auscultation and blood variables were determined by an enzymatic method. Univariate analysis of variance, one-way analysis of variance and the Scheffé post hoc test were used for statistical analysis (p < 0.05). Main findings. The three %BF groups differed significantly in terms of body weight and body circumference measures, with higher mean values being observed the higher the %BF. Fasting glycemia and high-density lipoprotein did not differ between groups, indicating the interference of other factors. BMI, WHR, blood pressure, total cholesterol, low-density lipoprotein, triglycerides, atherogenic index and atherogenic cholesterol were statistically similar in the overweight and obese groups and differed significantly from the healthy group. Conclusions. Abdominal, waist, hip circumference and body fat topography (arm, leg and trunk %BF) differ between the three %BF groups. None of the blood variables differed significantly between the overweight and obese groups. The cutoff %BF > 19 (measured by DXA) seems to be a good parameter to indicate cardiovascular risk factors in men.