Aliphatic aminocarboxylic acids inhibit at least two different antigen-antibody reactions. The degree of inhibition depends upon carbon chain length and the position of the amino group in relation to the carboxyl group.
The serum of patients with systemic lupus erythematosus may contain antibodies reacting in a variety of ways against several intracellular antigens. This report describes a new method of analyzing these antigen‐antibody reactions by immunoelectrophoresis on cellulose acetate membranes. The results show that abnormal sera may contain at least two different precipitating antibodies, one directed against a deoxy‐ribonucleohistone complex, and the other directed against an antigen that may be histone not attached to DNA.
BIOCHEMISTRY: GOLDBERG AND ATCHLEY 989 for certain proportions of (3-form and disordered coil. Here the fit in the 230 region is better with the constants of the sodium dodecyl sulfate-produced /-form. We are deeply indebted to Prof. J. T. Yang and Drs. E. S. Pysh and P. Urnes for numerous helpful and critical discussions and aid with the circular dichroic work.
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