No abstract

KOt-Bu/DMF promoted intramolecular addition of diarylmethanols to imines was developed. A series of 2,3-disubstituted indoles was obtained in good yields. A reaction mechanism of radical cyclization and subsequent dehydration is proposed.

Herein, we report the rational design of a DEVD-based heptapeptide hydrogelator 1 which is susceptible to caspase-3 (CASP3), and its isomeric control hydrogelator 2 with a DEDV-based heptapeptide sequence. Self-assembly of 1 in water results in flexuous, long nanofibers to form supramolecular hydrogel I with higher mechanical strength than that of hydrogel II which is composed of rigid, short nanofibers of 2. In vitro enzymatic analysis indicated that 1 is susceptive to CASP3 while 2 is not. 3-(4,5-dimethylthiazol-2-yl) 2,5 diphenyl tetrazolium bromide (MTT) and Western blot analyses indicated that DEDV-based hydrogelator 2 induces cell death via apoptotic pathway while the DEVD-based hydrogelator 1 minimizes cellular apoptosis induction.

Conversion of CO2 into value-added chemicals through electrocatalytic CO2 reduction reaction (CO2RR) is considered as an up-and-coming way to facilitate renewable closed carbon cycle and energy storage. Therefore, the development...

Direct addition of tetrahydroisoquinoline derived amides to arylalkenes has been achieved in the presence of KOt-Bu/DMF. Both intermolecular and intramolecular reactions could occur in good yields. α-Amido alkyl radicals are proposed to be generated under the reaction conditions. The reaction is efficient for the synthesis of seven-membered nitrogen heterocycles. A homoprotoberberine was prepared conveniently via this method.

Chiral amphiphilic conjugate catalysts were designed and synthesized by covalently connecting L-proline with an inexpensive natural product, isosteviol. These catalysts demonstrated remarkable efficiency in the asymmetric a-aminoxylation of aldehydes and ketones using nitrosobenzene in phosphate buffer solution, resulting in good to high yields and excellent enantioselectivities without using any additives. At pH 9.1, the amphiphilic catalysts showed a pH responsive ability in phosphate buffer solution, which facilitated the excellent O-selectivity reactions, illustrating a viable approach for the development of asymmetric supra-molecular catalysts.

No abstract

In the crystal structure of the title salt, C11H12N2 2+·2Cl−·H2O, the dication adopts a butterfly shape [dihedral angle between rings = 69.0 (1)°] with the water mol­ecule lying in the V-shaped cavity. Each O—H bond of the water molecule lies parallel to an aromatic ring and forms an O—H⋯Cl inter­action to a chloride anion. The methyl­ene C atom in the dication and the water O atoms lie on special positions of twofold site symmetry.