Enantioselective synthesis of 2-amino-4H-pyrans via the organocatalytic cascade reaction of malononitrile and α-substituted chalcones

Synthesis and Evaluation of 2-Amino-4H-Pyran-3-Carbonitrile Derivatives as Antitubercular Agents

“…2-Aminopyranopyridine-3-carbonitriles 2h-2n derived from monoenones 1h-1n were also prepared (Scheme 4) [12]. Cyclic enones 1h-1j reacted with malononitrile in the presence of triethylamine.…”

“…Recently we have developed efficient methods for the synthesis of homochiral 2-amino-4H-pyran-3-carbonitriles [11,12]. We are interested in the effect of chiral center of these compounds on the antitubercular activity.…”

Synthesis of Benzothiophene-Fused Pyran Derivatives via Piperidine Promoted Domino Reaction

“…Fused pyran ring existing in both numerous natural products and synthetic compounds is an important heteroatom framework [1][2][3][4][5], which demonstrate great function on pharmacological activities, antibacterial, antiviral, anticoagulant, antianaphylactic, anticancer, diuretic activities, neurodegenerative disorders, and so on [6][7][8][9][10]. Recently, 2aminochromenes are found to be employed as pigments, cosmetics, and agrochemicals [11][12][13].…”

The Investigation of Reaction of Various Thiophene Based Knoevenagel Adducts With Acetoacetanilide

“…A cascade reaction of malononitrile and αsubstituted calcone allowed to synthesize chiral multi-substituted amino-4H-pyrane derivatives. Alkoloids were checked up as catalyst in pyrane synthesis reactions [6].…”