No abstract

No abstract

No abstract

No abstract

No abstract

Cholesterol is a steroid compound found in animals and humans. Total cholesterol normal levels in rat is 10-54 mg/dL and triglyceride 26-145 mg/dL. Rice bran has a crude fiber content and antioxidants that can be used to resolve these conditions. This study aims to determine the effect of rice bran as therapy in the rats (Rattus norvegicus) high-cholesterol dietary model towards triglyceride levels and histopathologic of the aorta. In this research, rats (Rattus norvegicus) were divided into 5 groups with 4 repetitions. Group A as a negative control, group B was rat which fed with high cholesterol, group C was high-cholesterol diet model of rat with the 16% rice bran therapy/rat/day, group D was high-cholesterol diet model of rat with the 38% rice bran therapy/rat/day, and group E was high cholesterol diet model of rat with the 57% rice bran therapy/rat/day. Rice bran therapy performed for 21 days. Triglyceride levels were calculated by the GPO-PAP method and aortic histopathologic features were observed with HE staining (Hematoxylin-Eosin). The effect of rice bran on blood triglyceride levels was analyzed by one way ANOVA (Analysis of Variance) with α=5% and aortic histopathologic analysis was qualitatively descriptive. The results showed that rice bran therapy could significantly reduce triglyceride levels (p < 0.01) with a dose of 57%/rat/day to decrease triglyceride levels. Rice bran therapy also repaired aortic tissue histopathology of rat with high cholesterol diet model.

| There is an increase population growth in Indonesia. Therefore, it is necessary to control this through the use of antifertility agents. Both cepoka eggplant (Solanum torvum S.) and Kapok seeds (Ceiba pentandra G.) have a role as antifertility agents as contains solasodine and gossypol compounds respectively. This study aims to determine the difference between the effect of cepoka eggplant extract and Kapok seed as male antifertility agents on the expression of p53 protein in the seminiferous tubular tissue and the number of Leydig cells in rats. A total of 18 male Wistar rats, 2.5-3 months old and 190-320 g weight were randomly divided into 3 groups with 6 replicats, as follows: the negative control group (K-) without treatment, group 1 (G1) given 1 g/kg Cepoka eggplant extract, and group 2 (G2) admistered 0.1 g/kg Kapok seed extract. The results showed that the administration of 0.1 g/kg Kapok seed extract (Ceiba pentandra G.) significantly increased the expression of p53 protein and reduced the number of Leydig cells compared with the administration of 1 g/kg Cepoka eggplant extract (Solanum torvum S.). It was concluded that Kapok seed extract can be used as antifertility agent as increase the expressions of p53 protein and reduce the number of Leydig cells.Citation | Hendrawan VF, Cakrawati LS, Aulanniam A, Wulansari D, Oktanella Y, Agustina GC (2019). Impact of cepoka eggplant extract (solanum torvum s.) And kapok seed (ceiba pentandra g.) On expression of p53 protein and the number of leydig cells in rats. Adv. Anim. Vet. Sci. 7(9): 732-737.

No abstract