Background: Multinodular goitre (MNG) is a clinicopathological entity characterized by an increased volume of the thyroid gland with formation of nodules. The present study has been planned to study the various clinical presentations and diagnostic accuracy between operative findings and histopathological findings in a case of multinodular goitre.Methods: The present study was a hospital-based prospective study conducted in Dr D.Y. Patil Medical College, Hospital and Research Centre, Pune between July 2016 to September 2018. 100 patients aged between 15 to 75 yrs. clinically diagnosed as multinodular goitre were included.Results: FNAC finding of multinodular goitre in the study group showed colloid goitre was seen in 62 cases, 27 cases had multinodular goitre. 6 cases had neoplastic etiology, 3 cases had Hashimoto’s thyroiditis and 2 cases had papillary carcinoma of thyroid. HPE finding wise distribution showed that 10 cases were malignant, and 90 cases were benign. FNAC finding was significantly associated with histopathological finding in detecting malignant or benign lesion of multinodular thyroid gland and diagnostic accuracy of FNAC is 92%. Clinical finding comparison with operative finding showed that diagnostic accuracy of detecting malignant or benign lesion was only 35%. There was no significant difference among the two methods for detecting type of lesion in multinodular thyroid.Conclusions: Females are predominantly affected. About 8% cases of MNG are malignant. Considering the histopathological report as a gold standard, correlation of FNAC finding with histopathological finding was very much accurate and significant for detecting malignant and benign lesion of multinodular thyroid.

No abstract

No abstract

Abdominal masses have always been a dilemma for the surgeons and this problem is more so in retroperitoneal masses. In our case, the patient presented with retroperitoneal mass in the left lumbar region with no other specific local or systemic symptoms. The diagnosis of Castleman's disease was established only after histopathological examination of the mass after resection. Castleman's disease is an angiofollicular lymph node hyperplasia presenting either as a localized or a systemic disease. In our case, the patient presented with the localized form of the disease and as it is a rare presentation we are presenting this case.

Background: Aims and objectives of the study was to study the incidence of H. pylori infection in our Hospital. To find out the sensitivity and specificity of rapid urease test (RUT) and histopathological examination for the detection of H. pylori on gastric biopsy. To study the effect of anti H. pylori drugs by performing follow-up endoscopy in terms of positive or negative Rapid Urease Test and Histopathological Examination report.Methods: The study was conducted at Dr. D. Y. Patil Medical College and Hospital, DPU University, for a period of 2 years (from July 2012-September 2014) and is a prospective and comparative randomized type of study using 100 patients. The study was approved by the Institute’s Ethics Committee.Results: Data analysis showed that: In our study 84 patients (84%) were detected positive by RUT method. In our study 83 patients (83 %) were detected positive by HPE method. There was an association between RUT and HPE finding in study group with the sensitivity being 96.38 % and specificity being 74.47 %, PPV was 95.24% and NPV was 81.25%. At the time of follow up after taking anti H pylori treatment, 79 patients were RUT negative and 8 were RUT positive who were defaulters (not taken complete dose) and again started on treatment with the accuracy of the drug being 98.85 %. At the time of follow up after taking anti H pylori treatment 78 patients were HPE negative and 9 were HPE positive who were defaulters (not taken complete dose) and again started on treatment. There was an association between RUT and HPE finding at follow up with the sensitivity being 88.89 % and specificity being 100%, PPV was 100% and NPV was 98.73%.Conclusions: Our study reveals that RUT is accurate for the diagnosis of H. pylori infection and its use will serve as a good alternative to histology in management of patients with dyspepsia in resource poor environments, except in patients who need histology for reasons other than H. pylori diagnosis.