The aim of the present study was to assess the effect of iron and copper consumption on weight gain and development of oxidative stress in adipose tissue of rats. Control rats obtained pure drinking water. Iron-treated groups of animals obtained FeSO4•12H2O with drinking water in concentrations of 3 and 6 mg/l, while copper-treated rats obtained CuSO4 in concentrations of 4.88 and 9.76 mg/l. The animals of the 6th group received a mixture of FeSO4•12H2O and CuSO4 in the respective concentrations of 3 and 4.88 mg/l in drinking water. All animals received a standard chow. The final weight of rats from all the experimental groups, especially in those obtaining the combination of iron and cooper, exceeded the control values. Maximal weight of fat pads was observed in animals receiving drinking water with 3 mg/l FeSO4•12H2O, 4.88 and 9.76 mg/l CuSO4, and the mixture of FeSO4•12H2O and CuSO4. The maximal intensity of free radical processes, as estimated by the concentration of fluorescent modified amino acids and the intensity of chemiluminescence in adipose tissue homogenates, was observed in rats obtaining iron in the concentration of 3 mg/l in the drinking water.
There is a pressing issue related to combined oral introduction of heavy metals into a human body with drinking water and food products. It is caused by food products contamination, very high probability that metals migrate into water and plants from soils, ambient air, etc. The research goal was to hygienically assess combined oral introduction of heavy metals with drinking water and food products with subsequent population health risks assessment. The authors analyzed long-term data on structure and volumes of food products consumption and assessed population exposure under combined oral introduction of heavy metals (mercury, cadmium, arsenic, and lead) contained in drinking water and food products. Data were obtained from a regional information social-hygienic monitoring database and a regional office of the Federal Statistics Service. Both regional products and products delivered from other regions (or countries) were analyzed. It was detected that population in the region consumed food products per 1 person a year in a quantity which was by 93 kg higher than on average in the country. Calculated concentrations of the examined substances in food products and drinking water corresponded to hygienic standards. Dairy products had the first rank place as regards a contribution made into the overall exposure to lead, cadmium, and arsenic. The second and the third place belonged to vegetables and melons and grocery respectively. The first rank place as per a contribution made into the overall exposure to mercury belonged to vegetables and melons; the second place, to grocery; the third place, to dairy products. Non-carcinogenic risk assessment revealed that hazard quotients related to heavy metals contents in food products and drinking water were within acceptable risks limits. Total carcinogenic risk (TCR) was unacceptable (1.5Е-03.). A number of additional oncologic diseases in the region could reach 557 cases (during 70 years) under the worst scenario.
The ranking of municipal formations of the Orenburg region on the incidence of malignant neoplasms of the colon, rectosigmoidal junction and rectum, and the level of carcinogens in food and drinking water has been ranked. Based on average concentrations, the total coefficients of carcinogens supplied with drinking water from centralized water supply and food products were calculated. Priority carcinogens have been identified in drinking water and food products that affect the occurrence of colon cancer, rectosigmoidal connective and rectum, as well as the risk area, with an increased incidence of colon cancer, rectosigmoid and rectal cancer caused by a carcinogenic load in drinking water and food Products.
There have been developed models of multiple regression predicting cancer morbidity under the influence of carcinogens of drinking water, atmospheric air and soil. The environment quality assessment during the period from 2001 to 2010 was carried out on the basis of the laboratory research results realized in the framework of social hygienic monitoring. The most significant pollutants were revealed: cadmium, xylol and benzene in atmospheric air, nickel in drinking water and soil, oil products in water. The complex environment quality assessment detected that concentration of xylol in the air had an impact on the oncological morbidity in all localizations under study. The cancer morbidity of the mammary gland was proved to be the most ecologically dependent.
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