Stroke is a serious complication of diabetes but the risk factors for stroke in these patients are not fully defined. The aim of this retrospective study was to investigate the risk factors for stroke in patients with type 2 diabetes mellitus (T2DM). The group comprised 208 patients with T2DM, and the mean duration of followup was seven years (range 4-11 years). The incidence of stroke was investigated according to lymphocyte proliferation in response to insulin.Using cimetidine to inhibit cells with histamine receptors and indometacin to inhibit prostaglandin-synthesising cells, a higher incidence of stroke was found in patients with indirect cell-mediated immunity to insulin. Therefore, one of the risk factors for stroke in patients with T2DM is high activity of cells with histamine receptors and prostaglandin-synthesising cells. These cells suppress cell-mediated immunity to insulin and may have a role in promoting the development of insulin resistance. 2006;3:57-60 Diabetes Vasc Dis Res
AIM OF STUDY To develop a method for assessing the severity of obstructive jaundice (OJ) of non-neoplastic orogin on the basis of functional parameters of the liver and the activity of pathogenetic agents of hepatodepression.MATERIAL AND METHODS Clinical and laboratory studies of 142 patients with breast cancer of non-tumor origin. The indicators of the functional state of the liver, the index of plasma toxicity for albumin, and the content of malondialdehyde (MDA) were evaluated.RESUlTS Based on the assessment of a number of blood parameters - the content of total bilirubin (TB), the plasma toxicity index for albumin, the MDA level — the severity index of obstructive jaundice of non-neoplastic origin (SIOJ) was developed:SIOJ = IT1/ITn + TB1/TB + 5(MDA1/MDAn)where IT 1 is the plasma albumin toxicity index at the current moment, ITn is the normal albumin plasma toxicity index, TB1 is the current bilirubin content, TBn is the normal bilirubin content, MDA1 is the current malondialdehyde content, MDAn is the normal value. The index less than 13 indicates a mild severity, 14–21 is moderate severity, 22 and higher indicates a severe degree of OJ. The method increases the objectivity of determining the severity of non-neoplastic origin by establishing the severity of liver damage and the processes underlying it.CONClUSiON The suggested clinical and laboratory index allows the severity of obstructive jaundice to be objectively and quickly determined upon admission of a patient to the hospital and also adequate therapy to be initiated in case of severe degree for anticipation of possible post-operative complications, so the treatment should be focused on managing triggers of hepatodepression. The method is simple and available in medical institutions of various levels. The method is especially valuable when used in the dynamics of the early postoperative period.
Increasing the effectiveness of peritonitis treatment remains an urgent issue for abdominal urgent surgery. So far, several effective surgical technologies have been developed. However, conservative therapy in the early postoperative period is an object for development, including the target organ protection influence. The aim of the study is to determine the nephroprotective efficacy of complex treatment with remaxol in acute peritonitis. Materials and Methods. The authors examined 46 patients with acute peritonitis. The patients were divided into two groups: Groups 1 (comparison, n=26) received standardized treatment, Group 2 (main, n=20) was treated with remaxol. Research methods, in addition to routine ones, included the assessment of kidney functional state, endotoxicosis, and oxidative stress. Results. It is revealed that in acute peritonitis, the authors recorded substantial deviations in the functional state of the kidneys, such as endogenous intoxication, and oxidative stress. Maximum imbalance is diagnosed on the 1st day of the early postoperative period. The use of remaxol in the complex therapy of patients with acute peritonitis significantly improves the functional state of the kidneys, thus, optimizing the course of the early postoperative period and reducing the severity of endogenous intoxication. The positive effect of the drug is caused by its ability to manage the oxidative stress, a universal pathogenetic trigger for system and organ damage, including kidneys. Conclusions. Remaxol has a nephroprotective effect and improves the course of the early postoperative period.
Хронические опыты поставлены на беспородных собаках, которым экспериментально воспроизводился каловый перитонит. В первой группе (n=15) животным в раннем послеоперационном периоде проводилась антибактериальная и инфузионная терапия. Во второй группе (n=15) схему лечения после санации брюшной полости дополняли лазерной терапией и введением реамберина. В третьей группе (n=8) схема лечения соответствовала таковой второй группы с той лишь разницей, что включение в комплексную терапию указанных лечебных агентов производилось со 2-х суток. В контрольные этапы (1-е, 3-и, 5-е сутки) периода наблюдения животным выполняли забор крови, биопсию печени, почек и кишечника. Оценивались интенсивность эндогенной интоксикации, функциональное состояние печени, почек и кишечника. Установлено, при остром экспериментальном каловом перитоните нарушение функционального статуса печени, почек и кишечника происходит на фоне эндогенной интоксикации. Включение в комплексное лечение острого перитонита лазерной терапии и препарата метаболического типа действия повышает эффективность лечения, что проявляется существенным уменьшением функциональных расстройств исследованных органов на фоне уменьшения эндогенной интоксикации. Результативность такого рода терапии по коррекции функционального состояния органов детоксикации при отсроченном ее применении уменьшается в значительной степени. Ключевые слова: перитонит лазерная терапия, реамберин, печень, почки, кишечник, интоксикация.
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