Abstract.Following the results of a pilot study on studying of influence of an emoksipin, verapamil and a reamberin at acute pancreatitis it is possible to say that under the influence of these drugs in fabric structures of the inflamed pancreas there is a decrease in intensity of free radical processes of a lipopereokisleniye, activity of phospholipases, hypoxia phenomena. Level of antioxidant protection of fabric of body increases. In the first three days of supervision the accurate tendency to normalization of the transformed lipidic structure of fabric structures of a pancreas is revealed. At the same time these positive effects are noted in all experienced groups. It demonstrates that though pharmacological drugs are used multidirectional action (antioxidant emoksipin, an antigipoksant reamberin, inhibitor of calcium channels verapamil), they in a varying degree influence on studied pathological (membranodestruktivny, hypoxemic) processes, leading finally to reduction of their expressiveness. So, emoksipin found big ability to increase stability of membranes of pankreatotsit to pathological influence of molecular products the FLOOR, verapamil -to stopping of the activated phospholipases, reamberin -to a hypoxia. The question solution on the key (prevailing) mechanism in trigger processes of sharp pancreatitis of a definite answer has no. Undoubtedly only the fact that efficiency of antioxidant and inhibitor of calcic channels was rather higher. It suggests that free radical processes of a lipopereokisleniye and activity of fosfolipazny systems predetermine the level and nature of defeat of a cellular biomembrane of pankreatotsit already on the earliest terms of inflammatory process.
The purpose of the work is to estimate the efficiency of intraoperative neuromonitoring used as a means for preventing damage to the recurrent laryngeal nerve in thyroid surgery.The basis for the work is the analysis of surgical treatment in 120 patients with various diseases of a thyroid gland, of whom 60 patients being operated using intraoperative neuromonitoring.The surgical neuromonitor "Neurosun 400"was used for the purpose of monitoring ("INOMED", Germany). The main objectives of intraoperative neuromonitoring were the emergency detection and localization of a nerve, its exact differentiation from the surrounding tissues by means of a stimulator.Intraoperative neuromonitoring of a recurrent laryngeal nerve by means of the Neyrosan-400 device has considerably reduced time of searching the nerve. So, the time of search was averaged 9.2±0.8 min. in the control group, whereas in the main group -3.1±0.7 min. (р <0.05). As a result, the general time of operation has decreased.The general duration of operation in the control group of patients was averaged 63.7±6.1 min., in the main group -45.4±5.8 min. (р <0.05).The obligatory visualization is necessary for reliable prevention of damage to a recurrent laryngeal nerve during operation.The recurrent laryngeal nerve has an accurate minimum threshold of stimulation which is -0.5ma, no matter what the patient's age is.Using neuromonitoring in thyroid surgery with the Neyrosan-400 device allows both conducting emergency and accurate identification of a recurrent laryngeal nerve in all cases as well as avoiding traumatic damage.
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