Fe 3 O 4 nanoparticles were coated with a layer of citric acid, forming coordination bonds between citrate ions and iron ions. The resulting aqueous citrate ferrite colloid was used as a T 2 -weighted MRI negative contrasting agent. Sequential i.v. doses of citrate ferrite and Magnevist led to increases in MRI image contrast for 40 h and brightness for 30 min; scanning using a Bruker Biospec BC 70/30 USR biospectrotomograph yielded enhanced MRI images. This enhancement of MRI images was used to monitor oncogenesis during magnetohydrodynamic thermochemotherapy (MT) of mammary adenocarcinoma Ca 755 in female C57Bl/6j mice. Dextran ferrite colloid containing cyclophosphamide was tested as a magnetically directed antitumor agent using MT. Treatment of non-infiltrating tumors of volume » 30 mm 3 with six sessions of MT each lasting 30 min at 46°C led to 40% tumor regression and 300% increases in survival time. Treatment of infiltrating tumors of volume » 300 mm 3 in the same conditions yielded a 200% increase in survival time.
The paper presents the basic methods of disposal and recycling of waste activated sludge. We propose a new technology of neutralization of waste activated sludge and subsequent disposal in the form of an adsorbent for cleaning oil-contaminated wastewater and production of complex fertilizers, allowing to intensify the process of phytoremediation of soils from oil.
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