A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments. The hypoglycemic activity of 4 was evaluated against alloxan-induced diabetic mice. The test compound was administered at doses of 25, 50, and 100 mg/kg, p.o., 36 h after alloxan injection (60 mg/kg, i.v.). The alloxan-induced diabetic mice showed significant reduction in blood glucose after treatment with the test compound by 52% as compared to the positive control glibenclamide (54%) and the diabetic control (27%).
AIM: To compare the coagulation parameters in patients with preeclampsia and eclampsia with normotensive pregnant patients in Nainital district of Uttarakhand state. MATERIAL AND METHODS: From January 2012 to June 2013, coagulation indices including platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), bleeding time (BT) and clotting time (CT) were measured in 100 patients with preeclampsia and eclampsia and compared with 100 normotensive pregnant women. The patients with coagulopathies were excluded. RESULT: In preeclampsia and eclampsia, decrease in platelet count (157.18±56.66 lacs/cumm) was highly significant (p<0.001). PT, aPTT and CT were normal but BT (322.46±171.39 sec) was significantly prolonged (p<0.001) in pre eclampsia and eclampsia patients. CONCLUSION: The abnormalities pertaining to coagulation parameters in hypertensive disorders of pregnancy indicate the intravascular coagulation.
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