Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Chauhan, Priyanka; Rawat, Usha; Bisht, Vandana; Purohit, Ramkrishna

doi:10.14260/jemds/2014/2268

Cited by 18 publications

(18 citation statements)

References 7 publications

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“…Chauhan P found that in pre-eclampsia and eclampsia, decrease in platelet count (157.18±56.66 lacs/cumm) was highly significant (p<0.001). 8 This finding corroborated with this study.…”

Section: Platelet Countsupporting

confidence: 90%

Study of coagulation profile and platelet indices in pregnancy induced hypertension with special reference to preeclamptic and eclamptic patients

Haldar¹,

Barui

2020

Int J Res Med Sci

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Background: Hypertensive disorders of pregnancy affect about 10% of all pregnant women around the world. A variety of haematological abnormalities may occur in women with Pregnancy Induced Hypertension (PIH), thrombocytopenia being the most common. There is also a definite exaggeration of the hypercoagulable state during PIH. A strong relationship exists between the two most important causes of maternal mortality and morbidity worldwide: Preeclampsia and Post-partum hemorrhage. The aim of this study was to find out the changes that occur in the coagulation profile and platelet indices in PIH as compared to that in normal pregnancy and if they can be used as a reliable indicator of the onset and severity of Preeclampsia and eclampsia.Methods: This was a hospital based analytical prospective study carried out in R. G. Kar Medical College, between January 2017 to June 2018 on 120 patients with PIH. The study parameters included Platelet count, Platelet Distribution Width (PDW), Mean Platelet Volume (MPV), Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT).Results: The results showed significant decrease in platelet count in preeclampsia and eclampsia patients when compared to normotensive patients. Also, there was significant increase in MPV and PDW in preeclamptic and eclamptic patients. Coagulation profile showed increased PT and APTT both in preeclamptic and eclamptic patients with eclamptic patients having significantly higher APTT than other groups.Conclusions: Thus, authors came to the conclusion that platelet indices and coagulation profile can be used as a reliable early indicator of onset and severity of preeclampsia and eclampsia.

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“…Chauhan P found that in pre-eclampsia and eclampsia, decrease in platelet count (157.18±56.66 lacs/cumm) was highly significant (p<0.001). 8 This finding corroborated with this study.…”

Section: Platelet Countsupporting

confidence: 90%

Study of coagulation profile and platelet indices in pregnancy induced hypertension with special reference to preeclamptic and eclamptic patients

Haldar¹,

Barui

2020

Int J Res Med Sci

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“…Chauhan et al observed platelet count in cases as 157.18±56.66 x 10 9 /L and in controls as 222.93±97.94 x 10 9 /L. 20 Meshram DP observed platelet count 242±62 x10 9 /L in control group and 160±51 x10 9 /L in preeclampsia. 21 These authors also found significantly decreased platelet counts in pre eclampsia as compared to that in controls, similar to the present findings.…”

Section: Discussionmentioning

confidence: 95%

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

Gupta¹,

Gaur²,

Mishra³

et al. 2018

Int J Res Med Sci

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Background: Preeclampsia, the most common of hypertensive disorders of pregnancy is an idiopathic multisystem disorder affecting 2 – 10% of all pregnancies and together they form one member of the deadly triad, along with hemorrhage and infection that contribute greatly to the maternal morbidity and mortality rates. The identification of this clinical entity and effective management play a significant role in the outcome of pregnancy. Platelet count is emphasized to play a significant role in hemostasis mechanism of preeclampsia and the degree of thrombocytopenia increases with severity of preeclampsia. This study was conducted to find correlation of platelet count in severe preeclampsia, mild preeclampsia and normal subjects.Methods: Total 140 subjects, 70 control and 70 cases were enrolled in the study. Samples for platelet count were collected and estimation was carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22 along with Anova and student t-test.Results: The mean platelet count was significantly lower (p <0.05) in mild and severe preeclampsia than that in the normal pregnancy. Decreased platelet count in severe preeclampsia was significant compared to that in mild preeclampsia.Conclusions: The frequency of thrombocytopenia was found to be directly related with the severity of disease, so platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period.

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“…Alice Konijnenberg [21] observed that during preeclampsia there is a more extensively activated state of platelets while observing in Flow cytometric analysis when compared with normal pregnancy. Priyanka Chauhan et al [22] reported that platelet count decreased significantly among preeclampsia and eclampsia and PT, aPTT, CT were normal but BT was prolonged.…”

Section: Slmentioning

confidence: 99%

A Study of Fibrinogen, Prothrombin Time, Serum Transaminases in Normal Pregn Ancy and Preeclampsia and Their Significance as a Diagnostic Tool Among Preecla M Psia Patients

Ray¹

2015

jebmh

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BACKGROUND Preeclampsia is the important cause of perinatal mortality and morbidity. It causes marked deterioration in function of various organs and systems. Disseminated intravascular Coagulation (DIC) is a characteristic feature of PIH. AIMS The aim of the present study is to show the biochemical changes such as Fibrinogen, Prothrombin time, Serum Transaminases which occur in normal pregnancy and in preeclampsia and comparison with normal female subjects. SETTINGS AND DESIGN Prospective randomized case-control study. METHODS AND MATERIAL A total of 120 patients were selected for the testing of Fibrinogen, Prothrombin time and serum transaminase levels who were divided into three groups (40 patients in each group) for correlating the values of biochemical changes and to understand the significance between the groups. Graph pad Software was used for statistical Analysis. RESULTS Fibrinogen levels were higher in Normal pregnancy and preeclampsia group than Non-pregnant women. Significant prolongation of Prothrombin time was seen among preeclampsia group when compared with Non-pregnant women. SGOT and SGPT were elevated more in Preeclampsia group when compared to other two groups. The estimated variables (Fibrinogen, Prothrombin time, SGOT, SGPT) have shown that there is a good correlation of variables between non pregnant and preeclampsia groups and also normal pregnancy and preeclampsia groups which was statistically significant. CONCLUSION Detection of these changes in early period, can stop the progression towards Eclampsia and will be useful to start the appropriate treatment.

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Comparison of Cogulation Profile in Pre Eclamptic and Eclamptic Patients With Normotensive Pregnant Patients

Cited by 18 publications

References 7 publications

Study of coagulation profile and platelet indices in pregnancy induced hypertension with special reference to preeclamptic and eclamptic patients

Study of coagulation profile and platelet indices in pregnancy induced hypertension with special reference to preeclamptic and eclamptic patients

A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

A Study of Fibrinogen, Prothrombin Time, Serum Transaminases in Normal Pregn Ancy and Preeclampsia and Their Significance as a Diagnostic Tool Among Preecla M Psia Patients

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