A Study of Fibrinogen, Prothrombin Time, Serum Transaminases in Normal Pregn Ancy and Preeclampsia and Their Significance as a Diagnostic Tool Among Preecla M Psia Patients

Abstract

BACKGROUND Preeclampsia is the important cause of perinatal mortality and morbidity. It causes marked deterioration in function of various organs and systems. Disseminated intravascular Coagulation (DIC) is a characteristic feature of PIH. AIMS The aim of the present study is to show the biochemical changes such as Fibrinogen, Prothrombin time, Serum Transaminases which occur in normal pregnancy and in preeclampsia and comparison with normal female subjects. SETTINGS AND DESIGN Prospective randomized case-control study. METHODS AND MATERIAL A total of 120 patients were selected for the testing of Fibrinogen, Prothrombin time and serum transaminase levels who were divided into three groups (40 patients in each group) for correlating the values of biochemical changes and to understand the significance between the groups. Graph pad Software was used for statistical Analysis. RESULTS Fibrinogen levels were higher in Normal pregnancy and preeclampsia group than Non-pregnant women. Significant prolongation of Prothrombin time was seen among preeclampsia group when compared with Non-pregnant women. SGOT and SGPT were elevated more in Preeclampsia group when compared to other two groups. The estimated variables (Fibrinogen, Prothrombin time, SGOT, SGPT) have shown that there is a good correlation of variables between non pregnant and preeclampsia groups and also normal pregnancy and preeclampsia groups which was statistically significant. CONCLUSION Detection of these changes in early period, can stop the progression towards Eclampsia and will be useful to start the appropriate treatment.