A comparison of platelet count in severe preeclampsia, mild preeclampsia and normal pregnancy

Abstract

Background: Preeclampsia, the most common of hypertensive disorders of pregnancy is an idiopathic multisystem disorder affecting 2 – 10% of all pregnancies and together they form one member of the deadly triad, along with hemorrhage and infection that contribute greatly to the maternal morbidity and mortality rates. The identification of this clinical entity and effective management play a significant role in the outcome of pregnancy. Platelet count is emphasized to play a significant role in hemostasis mechanism of preeclampsia and the degree of thrombocytopenia increases with severity of preeclampsia. This study was conducted to find correlation of platelet count in severe preeclampsia, mild preeclampsia and normal subjects.Methods: Total 140 subjects, 70 control and 70 cases were enrolled in the study. Samples for platelet count were collected and estimation was carried out by the auto-analyzers. The statistical evaluation is done using SPSS version 22 along with Anova and student t-test.Results: The mean platelet count was significantly lower (p <0.05) in mild and severe preeclampsia than that in the normal pregnancy. Decreased platelet count in severe preeclampsia was significant compared to that in mild preeclampsia.Conclusions: The frequency of thrombocytopenia was found to be directly related with the severity of disease, so platelet count can be used as a simple and cost effective tool to monitor the progression of preeclampsia, thereby preventing complications to develop during the gestational period.

A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

“…A study conducted in Asia [ 49 ] came to the same conclusion. A study conducted in Korea found a statistically significant positive association between PDW and MAP, while other PLT indices did not demonstrate a significant correlation, contrary to our findings [ 29 ]. However, another investigation identified MPV as a pre-eclampsia severity marker [ 51 ].…”

Platelet Counts and Indices Are Altered in Pre-Eclampsia

“…Analysis of platelet counts according to gestational period revealed a significant decrease of platelets from 24 weeks onwards in PE group compared to normotensive group (Table 4). Similar results in PE women about platelet counts were obtained by Gupta A et al, Al Sheeha et al, Gupta A et al, Annam V et al, in their studies [2][3][4][5] We also, observed a significant thrombocytopenia in severe pre-eclampsia women compared to those with mild (Table 5), which was in corroboration with studies by Gupta A et al, Gupta A et al, Somya et al [2,4,6]. However, Ceyhan and coworkers, found no significant difference between the platelet count in pre-eclamptic and normotensive pregnant control women [7].…”

Association between preeclampsia and prostasin polymorphism in Pakistani females

“… 25 , 26 Although patients in both groups were age-matched in between 20-40 years, but even in this range we found older age females in the preeclampsia group ( p <0.02) as compared to the control group which shows that elder age is a risk factor for preeclampsia. Similar results were shown by Dong et al 16 However, Gupta et al, 27 and Priyadarshini et al, 28 observed no significant differences between the mean gestational age of patients and controls. This discordance may be because the latter study only included subjects having gestational ages higher than 20 weeks.…”