Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from <i>Stephania glabra</i> tubers

Semwal, Deepak Kumar; Rawat, Usha; Semwal, Ruchi Badoni; Singh, Randhir; Singh, Gur Jas Preet

doi:10.1080/10286020903117325

Cited by 27 publications

(23 citation statements)

References 8 publications

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“…We identified 6 molecules isolated from 6 different plants, Aconitum japonicum , Ervatamia officinalis , Solanum nudum , Solanum sodomaeum , Stephania cepharantha and Tabernaemontana eglandulosa (see Table S2), that meet these criteria. The related species with described antidiabetic properties are Aconitum carmichaelii [33], Aconitum moschatum [2], Aconitum violaceum [2], Ervatamia microphylla [55], Solanum lycocarpum [56], Solanum nigrum [57], Solanum xanthocarpum [58], Stephania hernandifolia [59], Stephania glabra [60], Stephania tetrandra [61], and Tabernaemontana divaricata [55]. Therefore, it is plausible to hypothesize that these 6 plants could also have antidiabetic properties mediated, at least partially, by the inhibition of DPP-IV.…”

Section: Resultsmentioning

confidence: 99%

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

et al. 2012

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BackgroundNatural extracts play an important role in traditional medicines for the treatment of diabetes mellitus and are also an essential resource for new drug discovery. Dipeptidyl peptidase IV (DPP-IV) inhibitors are potential candidates for the treatment of type 2 diabetes mellitus, and the effectiveness of certain antidiabetic extracts of natural origin could be, at least partially, explained by the inhibition of DPP-IV.Methodology/Principal FindingsUsing an initial set of 29,779 natural products that are annotated with their natural source and an experimentally validated virtual screening procedure previously developed in our lab (Guasch et al.; 2012) [1], we have predicted 12 potential DPP-IV inhibitors from 12 different plant extracts that are known to have antidiabetic activity. Seven of these molecules are identical or similar to molecules with described antidiabetic activity (although their role as DPP-IV inhibitors has not been suggested as an explanation for their bioactivity). Therefore, it is plausible that these 12 molecules could be responsible, at least in part, for the antidiabetic activity of these extracts through their inhibitory effect on DPP-IV. In addition, we also identified as potential DPP-IV inhibitors 6 molecules from 6 different plants with no described antidiabetic activity but that share the same genus as plants with known antidiabetic properties. Moreover, none of the 18 molecules that we predicted as DPP-IV inhibitors exhibits chemical similarity with a group of 2,342 known DPP-IV inhibitors.Conclusions/SignificanceOur study identified 18 potential DPP-IV inhibitors in 18 different plant extracts (12 of these plants have known antidiabetic properties, whereas, for the remaining 6, antidiabetic activity has been reported for other plant species from the same genus). Moreover, none of the 18 molecules exhibits chemical similarity with a large group of known DPP-IV inhibitors.

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Section: Resultsmentioning

confidence: 99%

Identification of Novel Human Dipeptidyl Peptidase-IV Inhibitors of Natural Origin (Part II): In Silico Prediction in Antidiabetic Extracts

et al. 2012

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“…The test compound was administered at doses of 25, 50, and 100 mg/kg, p.o., 36 h after alloxan injection (60 mg/kg, i.v.). The alloxan-induced diabetic mice showed significant reduction in blood glucose after treatment with the test compound by 52% as compared to the positive control glibenclamide (54%) and the diabetic control (27%) (Semwal et al, 2010b). S. tetrandra S. Moore roots increases the blood insulin level and reduces the blood glucose level in streptozotocin diabetic mice.…”

Section: Anti-hyperglycemic Effectmentioning

confidence: 91%

“…Stephania glabra (Roxb.) Miers (+)-Pronuciferine (33), gindarine, gindaricine, gindarinine, hyndarine, magnoflorine, N-thyloxystephanine, N-methylhydoxystepharine, remerine, stephararine, cycleanine (28), rotundine, capaurine (34), corydalmine (35), stepholidine (36), stepharine (9), protoberberine, palmatine (37), dehydrocorydalmine (38), jatrorrhizine (39), stepharanine (40), columbamine (41), N-desmethycycleanine (42), corynoxidine (43) (Chaudhary and Siddiqui, 1950;Chaudhary et al, 1952;Chopra et al, 1956;Cava et al, 1964Cava et al, , 1968Kin et al, 1965;Robinovich et al, 1965;Shchelchkova et al, 1965;Doskotch et al, 1967;Dhar et al, 1968;Thu and Nuhn, 1971;Khanna et al, 1972;Patra et al, 1980;Bhakuni and Gupta, 1982;Bhakuni, 1984;Mahatma et al, 1987;Anonymous, 1989;Rastogi and Mehrotra, 1991;Duke, 1992;Das et al, 2004), 11-hydroxypalmatine (44) (Semwal et al, 2010b), glabradine (45) and gindarudine (46) (Semwal and Rawat, 2009a,b).…”

Section: Stephania Excentrica H S Lomentioning

confidence: 96%

The genus Stephania (Menispermaceae): Chemical and pharmacological perspectives

Semwal¹,

Badoni

Semwal

et al. 2010

Journal of Ethnopharmacology

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134

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“…However, another plant, S. glabra, the roots of which were coadministered with roots of C. trilobata by the Kuch healers for treatment of diabetes, reportedly contains 11-hydroxypalmatine, which demonstrated hypoglycemic activity in alloxan-induced diabetic mice. 20 It is also interesting that the Kuch healers administered a combination of the roots of C. trilobata and S. glabra for 30 days only. During only this time, eating of molasses was forbidden.…”

mentioning

confidence: 99%