3′,5′-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or “microdomains.” In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.
In this work we reviewed the key antimitochondrial and antinuclear antibodies in primary biliary cholangitis -an autoimmune cholestatic disorder with destruction of intralobular biliary ductules. Since the discovery of antibodies to PDC-E2 component of cholangiocyte mitochondrial membrane, more than 60 antimitochindrial and antinuclear antibodies against various cellular components of cholangiocytes have been described to date, which have primary diagnostic and clinical value in identifying the disease progression and prognosis.
This review is devoted to one of the vital topics in cardiovascular surgery -pathophysiologyof an aortopathy in case of bicuspid aortic valve. In the article reviewed the modern point of view on a problem considering new achievements in genetics, molecular biology and altered haemodynamic.Key words: aortic aneurysm-bicuspid aortic valve-metalloproteinase.
ТұжырымдамаӘдебиетке болжамдалған шолу қантамырлық-жүрек хирургиясының өзекті тақырыптарының бірі -екі жақтаулы аорталық қақпашасы бар пациенттерде патофизиологиялық аортопатияның ерекшеліктеріне арналған. Мақалада генетикадағы, молекулярлық биологиядағы, гемодинамика патологиясындағы жаңа жетістіктер ескеріле отырып, проблемаға заманауи тұрғыдағы көзқарас берілен.Маңызды сөздер: аорта аневризмі -екі жақтаулы аорталық қақпаша -металлопротеиназдар.оСоБенноСти патофизиологии аортопатии у пациентов С двуСтворчатыМ аортальныМ клапаноМ. Сейдалин а.о. 1 ,туганбеков т.у. 2 , диколаев в.д.
2,3, айталиев С.е 3 .1 «Городской кардиологический центр», отделение кардиохирургии, Алматы, Казахстан 2 «Медицинский Университет Астана», кафедра хирургии, Астана, Казахстан 3«Национальный научный медицинский центр», отделение кардиохирургии, Астана, Казахстан
Резюме.Предполагаемый обзор литературы посвящен одной из актуальных тем в сердечно-сосудистой хирургии -патофизиологии аортопатии при двустворчатом аортальном клапане. В статье дан современный взгляд на проблему с учетом новых достижений в генетике, молекулярной биологии, патологии гемодинамики.Ключевые слова: аневризма аорты -двустворчатый аортальный клапан -металлопротеиназы.
To carry out comparative analysis of the various surgical methods in patients with thoracic aorta pathology (aneurism, dilatation, dissection) in combination with bicuspid aortic valve in comparison to tricuspid aortic valve patients and to choose most appropriate approach of the surgical treatment in correlation with thoracic aorta sizes.Material and methods: In this work 212 case records of two patient groups with thoracic aorta pathology were analyzed, operated from 2013 until 2015 in cardiothoracic department of the "National Scientific Medical Center" JSC, to whom 4 surgical approaches were applied: Bentall de Bona procedure, supracoronary aorta replacement procedure, David procedure, Borst procedure.Results: Usage of Bentall de Bona procedure in patients with bicuspid aortic valve was related to less risk of postoperative complications in comparison with the group of tricuspid aortic valve patients (17,5% vs 39,5%, p=0,01). Surgical treatment with the usage of David procedure in observation group with BAV eliminates aortic valve insufficiency (degree of aortic valve insufficiency pre and postoperative -2,3 ± 1,3 and 0,9 ± 1,1 respectively, p=0,04).Conclusion: Surgical treatment of thoracic aorta pathology in patients with bicuspid aortic valve (mainly with stenosis) with the usage of Bentall de Bona approach is accepted as reasonable because it eliminates most considerably the implications of aortopathy and in this regard considered to be the most effective. David procedure is indicated to patients with pathology of thoracic aorta in combination with bicuspid aortic valve (mainly with insufficiency).
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