Antimitochindrial and antinuclear antibodies in primary biliary cholangitis

Saipiyeva, Dana; Askarov, Manarbek; Tuganbekov, Turlybek; Rustemova, Kulsara; Grigorevsky, Vladimir; Tostanovskaya, Nina

doi:10.23950/1812-2892-jcmk-00681

Cited by 1 publication

(3 citation statements)

References 36 publications

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“…Disruption of apoptosis is considered a trigger of PBC and already in the asymptomatic stage leads to the development of small bile duct ductulopenia, one of the early morphologic signs of the disease[ 73 ]. Apoptosis depends on mitochondrial permeabilization associated with excessive intracellular accumulation of bile acids[ 74 - 76 ].…”

Section: Mechanism Of Cholangiocyte Damage and Destabilization Of Bil...mentioning

confidence: 99%

“…Further solubilization by bile acids of phospholipids and cholesterol from the inner membrane and destruction of mitochondria can lead to the release and degradation of PDC. The latter includes three enzymes: E1 PDC, E2 PDC, and E3 PDC[ 73 ]. Each of these enzymes, in addition to the protein part, has cofactors: E1 PDC contains thiamine pyrophosphate as a cofactor; E2 PDC contains lipoic acid and coenzyme A; and E3 PDC contains flavin adenine dinucleotide and nicotinamide adenine dinucleotide.…”

Section: Mechanism Of Mitochondrial Permeabilization and Amas Formationmentioning

confidence: 99%

“…The PDC is a very important metabolic enzyme. PDC functions in every cell and is required for the conversion of pyruvate to acetyl-CoA, which is incorporated into the Krebs cycle and is essential for the body to obtain energy in the form of ATP[ 73 ]. As mitochondria in cholangiocytes permeabilize and PDC becomes involved in AMAs production, there is a gradual decrease in ATP synthesis.…”

Section: Dysfunction Of the Pdc Complex And The First Clinical Signs ...mentioning

confidence: 99%

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New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

Reshetnyak,

Maev

2023

World J Gastroenterol

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Acute pancreatitis (AP) is a potentially life-threatening inflammatory disease of the pancreas, with clinical management determined by the severity of the disease. Diagnosis, severity prediction, and prognosis assessment of AP typically involve the use of imaging technologies, such as computed tomography, magnetic resonance imaging, and ultrasound, and scoring systems, including Ranson, Acute Physiology and Chronic Health Evaluation II, and Bedside Index for Severity in AP scores. Computed tomography is considered the gold standard imaging modality for AP due to its high sensitivity and specificity, while magnetic resonance imaging and ultrasound can provide additional information on biliary obstruction and vascular complications. Scoring systems utilize clinical and laboratory parameters to classify AP patients into mild, moderate, or severe categories, guiding treatment decisions, such as intensive care unit admission, early enteral feeding, and antibiotic use. Despite the central role of imaging technologies and scoring systems in AP management, these methods have limitations in terms of accuracy, reproducibility, practicality and economics. Recent advancements of artificial intelligence (AI) provide new opportunities to enhance their performance by analyzing vast amounts of clinical and imaging data. AI algorithms can analyze large amounts of clinical and imaging data, identify scoring system patterns, and predict the clinical course of disease. AI-based models have shown promising results in predicting the severity and mortality of AP, but further validation and standardization are required before widespread clinical application. In addition, understanding the correlation between these three technologies will aid in developing new methods that can accurately, sensitively, and specifically be used in the diagnosis, severity prediction, and prognosis assessment of AP through complementary advantages.

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Section: Mechanism Of Cholangiocyte Damage and Destabilization Of Bil...mentioning

confidence: 99%

Section: Mechanism Of Mitochondrial Permeabilization and Amas Formationmentioning

confidence: 99%

Section: Dysfunction Of the Pdc Complex And The First Clinical Signs ...mentioning

confidence: 99%

See 1 more Smart Citation

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

Reshetnyak,

Maev

2023

World J Gastroenterol

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Antimitochindrial and antinuclear antibodies in primary biliary cholangitis

Cited by 1 publication

References 36 publications

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

New insights into the pathogenesis of primary biliary cholangitis asymptomatic stage

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