High-intensity focused ultrasound ablation: a non-surgical approach to treat advanced and complicated liver alveococcosis

Zhampeissov, Nurlan; Manap, Erlan; Rustemova, Kulsara; Fedotovskikh, Galina; Tuganbekov, Turlybek; Иманкулов, С. Б.; Gaipov, Abduzhappar

doi:10.1007/s10396-018-0914-x

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Current study results have shown similarity with those of other researchers revealing that high intensity ultrasound resection efficacy in uncomplicated cases of patients with Echinococcus multilocularis in the liver, implying the destruction of protoscolices, lamellar and germinal layers of the alveolar cyst larvae causing death of morphologically transformed cells which in turn cause liver necrosis (14). Results of biopsy examination after eradication confirmed the damage of impact to protoscolices and cellular components in the alveolar cysts, thus high intensity focused ultrasound considered a promising treatment for alveolar echinococcosis (14), also Imankulov et al (20) observed the destructive changes on alveococcosis with irregular forms and destroyed structures of the outer cuticular membrane, increase in neutrophil cells, eosinophils and macrophages. Thin sections showed membranes of alveolar cysts with different thickened dissociated and ripped, and the cells of germinal layer were desquamated and the nuclei of cells were lysed and the cytoplasm was vacuolated.…”

Section: Discussionsupporting

confidence: 88%

“…Ultrasound waves are a physical therapeutic method where non-ionizing radiation is applied in the form of mechanical sonicated on the tissues to produce heat. Ultrasound has been used to detect variety of diseases, including parasitic infections since 1970 (13), High Intensity Focused Ultrasound (HIFU) was initially used to treat cancer (14). It was used in the 1940s to treat brain diseases such as Parkinson's disease (15), uterine fibroids and prostate tumors (16).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Application of ultrasound contra infection with secondary hydatidosis in mice

Ramdan¹,

Ali²

2020

IJVS

View full text Add to dashboard Cite

The present research explained the impact of ultrasound on the viability of Echinococcus granulosus protoscolices in vitro application of fixed frequency waves at 20000 pulse/sec and 1.8 w/cm 2 , with different exposing periods, thirty, twenty, fifteen, twelve, ten and five seconds respectively, subsequently prevention of mice against interjected with minor hydatid cysts, in comparison with the control animals infected with protoscolices without exposure to ultrasound waves, depending on many criteria including the numbers, weights and diameters of developed hydatid cysts. The results displayed an obvious impact of ultrasound waves on Echinococcus granulosus protoscolices viability number by increase of exposure period in vitro, in addition to a decrease of 100% of hydatid cysts numbers in the dealt ones with 17% fertility exposed for 20 seconds, the reduction rate was 99.23% in the group of fertility 35% which exposed for 15 seconds, after four and five months of infection.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Application of ultrasound contra infection with secondary hydatidosis in mice

Ramdan¹,

Ali²

2020

IJVS

View full text Add to dashboard Cite

show abstract

“…Imankulov for the first time proposed the use of NIFU as a mini-invasive method of treatment of hydatidosis and alveolar echinococcosis of the liver in conditions of continuing severe emidemiological situation and unsolved many issues of the course, diagnosis and treatment of hepatic echinococcosis [3][4][5]. The developed indications and contraindications for HIFU use in hepatic echinococcal lesions, permissible sizes of parasitic masses, selection of optimal HIFU power, analysis of immediate and long-term results, comparative assessment of traditional surgical intervention and HIFU ablation were the basis for positive results and effective treatment of alveolar and hydatid liver echinococcosis by HIFU ablation [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Morphology of echinococcal liver lesions during treatment with high-intensity focused ultrasound

Fedotovskikh¹,

Shaymardanova²,

Zhampeissov

2022

J CLIN MED KAZ

Self Cite

View full text Add to dashboard Cite

The purpose of morphological studies was to study pathogenetic mechanisms of the therapeutic effect of HIFU ablation on hepatic echinococcosis.Material and methods: Ablation of echinococcal cysts and alveococcal liver lesions no larger than 5 cm in size with high-intensity focused ultrasound was performed on JC Focused Ultrasound Therapeutic System (China). Biopsy material of hepatic echinococcal masses in 37 patients after HIFU-ablation were taken for morphological light-optical and electron microscopic studies.Results: Protoscolexes lost their superficial syncytial layer, the parenchyma looked vacuolized, the disembodied heads with suckers and hooks were fragmented and separated from the body. Small vacuolization of hyaloplasm, homogenization of membranes and mitochondrial matrix, blurring of organelle contours in parenchymatous protoscolex cells were observed. Laminar shells of brood capsules and larvocysts of echinococcus were homogenized and ruptured, germinative cells were sloughed off. The laminar and germinal sheaths of the alveolar vesicles were irregularly thickened, unfolded, ruptured, and surrounded by necrotized liver cells and structureless masses. Destructively altered stem cells and calcareous calcium corpuscles of the laryngeal membrane were observed electron microscopically.Conclusion: Morphological data revealed destructive effect of HIFU ablation on mature and germinative forms of hydatid and alveolar echinococcus of the liver, as well as the safety of the selected optimal HIFU power on the surrounding hepatic tissue, which explains the absence of recurrence and confirms high effectiveness of HIFU ablation as a minimally invasive method of treatment of echinococcal growths of certain acceptable sizes.

show abstract

“…Since 1970 ultrasound has been used to detect a variety of diseases. High intensity focused ultrasound (HIFU) was also used initially to treat cancer like prostate tumors, brain diseases such as Parkinson's disease, treatment of uterine fibroids and prostate tumors (8)(9)(10). Ultrasound has also been used extensively in medical diagnosis and increasingly for therapeutic purposes as it has been applied in lithotripsy to destroy kidney stones and as a surgical tool to remove tumor tissue and as a tool for drug delivery (11).…”

Section: Introductionmentioning

confidence: 99%

Effect of ultrasound on protoscoleces of Echinococcus granulosus in vitro and in vivo

Ali¹,

Ramadhan²

2021

IJVS

View full text Add to dashboard Cite

The current study was designed to investigate the effect of ultrasound on the protoscoleces of Echinococcus granulosus by enforcing steady numeral of frequencies during a certain interval (20000 pulse/s) (1.8 w/cm 2 ), using exposure time 30,20,15,12,10 and 5s, individually and respectively. Consequently, six albino mice groups were immunized against cystic echinococcosis, which injected with exposed protoscoleces, to acquire specific cell-mediated immunity, called delayed type-hypersensitivity (DTH) which assessment by measurement the foot pad density. The results displayed significant excess (P≤ 0.001) of DTH by increase of foot pad thickness in injected groups. The results showed maximum thickness of 1.54 mm, 1.4mm, 0.9 mm. after 3h, 24h, and 48h postinjection, respectively, that compared with the thickness of control group 1.072, 0.638, 0.328 mm, respectively, during five months of experiment. The present research exhibited the action of ultrasonication technique on the viability of Echinococcus granulosus protoscoleces in vitro. Conclusion, Ultrasound frequencies used in the present study could be have consequential impact on the cellular immunity in albino mice.

show abstract

High-intensity focused ultrasound ablation: a non-surgical approach to treat advanced and complicated liver alveococcosis

Cited by 4 publications

References 13 publications

Application of ultrasound contra infection with secondary hydatidosis in mice

Application of ultrasound contra infection with secondary hydatidosis in mice

Morphology of echinococcal liver lesions during treatment with high-intensity focused ultrasound

Effect of ultrasound on protoscoleces of Echinococcus granulosus in vitro and in vivo

Contact Info

Product

Resources

About