A remarkable, efficacious, and environmental friendly one‐pot procedure affianced for the synthesis of 1,2,3‐triazoles by 1,3‐dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco‐friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14‐alpha‐demethylase (PDB ID: 3KHM) with excellent C‐score values. The antifungal screening of synthesized compounds revealed promising activity.

The innovation of facile, efficient and mild procedures utilizing contemptible, conveniently separable and reusablesolid catalysts that overcome obstacles are invariably in demand. Hence, a straightforward one-pot multicomponent reaction (MCR) and an expedient procedure for the synthesis of pyran annulated heterocycles 5 a-k and 6 l-v is developed using Chitosan-Zinc oxide (CS-ZnO) hybrid nanocatalyst. Use of aqueous medium is one of the major highlight of the present protocol. This protocol renders ease of operation, facile work up and magnified yields (90-95 %) as well as explores the use of modified polymeric substrates in the organic synthesis.

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