Cu microcrystals garnished with copper nanoparticles catalyzed one‐pot facile synthesis of novel 1,2,3‐triazoles via click chemistry as antifungal agents

Abstract

A remarkable, efficacious, and environmental friendly one‐pot procedure affianced for the synthesis of 1,2,3‐triazoles by 1,3‐dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco‐friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14‐alpha‐demethylase (PDB ID: 3KHM) with excellent C‐score values. The antifungal screening of synthesized compounds revealed promising activity.

Fe3O4 Nanoparticles Catalyzed Tandem Synthesis of Fluorescent 3‐(4,5‐diaryl‐1H‐imidazol‐2‐yl) quinoline‐2‐amines: Solvatochromic, DFT and Biological Studies

“…In view of the above discussion, we integrated the quinoline to imidazole along with tandem replacement of chloro substituent on quinoline by NH 2 to form 3-(4,5-diaryl-1H-imidazol-2-yl) quinolin-2-amines 4 k-z by MCR approach. IR, 1 H NMR, 13 C NMR, LCMS spectral data, and elemental analyses confirmed the structures of these hybrid molecules. In this protocol Fe 3 O 4 nanoparticles were successfully used as nano catalysts and the fluorescent, solvatochromic and DFT studies followed by molecular docking investigations to forecast the binding affinities at the active site of the Candida albicans dihydrofolate reductase enzyme (PDB ID:1AI9) and Novobiocin (PDB ID: 4URO) were carried out.…”

“…The reaction in presence of Fe 3 O 4 NPs (20 mg) was performed by refluxing in ethanol at 100 °C for 14 hours (Table 1, entry 12) and the observed yield was 97 %. Further, when we increased the catalytic amount of Fe 3 O 4 NPs to either 25 mg or 30 mg in ethanol, there was no significant increase in the yield was observed (Table 1, entries [13][14]. Thus, as the catalyst amount was increased to 30 mg with a variety of other solvents, viz., methanol, t-butanol, ethyl acetate, and H 2 O (Table 1, Entries 14 À 18), the yield was not increased significantly.…”

“…The compounds were 2. The electronic supplementary information contains the experimental methods for generating the title compounds and their FT-IR, 1 H NMR, 13 C NMR, and LCMS spectra.…”

“…It is well known that newer catalysts have been produced and used in the production of novel organic compounds. So also nanoparticles of Fe, Cu, Ir, Pd, Pt, Ag, Au, and their oxide derivatives have been extensively employed in organic synthesis [13,14] . Among them the Fe 3 O 4 nanoparticles were prepared using various methods such as sol‐gel, electrodeposition, thermal decomposition, hydrothermal, electrochemical etc [15] .…”

“…So also nanoparticles of Fe, Cu, Ir, Pd, Pt, Ag, Au, and their oxide derivatives have been extensively employed in organic synthesis. [13,14] Among them the Fe 3 O 4 nanoparticles were prepared using various methods such as sol-gel, electrodeposition, thermal decomposition, hydrothermal, electrochemical etc. [15] However, in most of these methods, the preparation of Fe 3 O 4 NPs on a larger scale was difficult due to the expensive and complicated procedure.…”